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FLASH GENE
Symbol TTYH2 contributors: mct/npt - updated : 31-08-2009
HGNC name tweety homolog 2 (Drosophila)
HGNC id 13877
Location 17q25.1      Physical location : 72.209.695 - 72.258.155
Synonym name tweety 2
Synonym symbol(s) C17orf29, MGC126172, MGC4837
DNA
TYPE functioning gene
STRUCTURE 48.46 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D17S1807 - TTYH2 - D17S1163 - qter
Authors Rae(01)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3468 58.6 534 - He (2008)
8 - 3278 23.4 213 - He (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   highly
Nervousbrain   highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular N terminal domain including a RGD
  • five putative transmembrane segments (5TM)
  • one putative casein kinase II
  • two potential PRKC phosphorylation sites
  • four N linked glycosylation sites
  • five potential N myristoylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Ttyh2
    homolog to Drosophila tweety
    intraspecies paralog to TTYH1
    Homologene
    FAMILY
  • tweety family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play an important role in regulating both proliferating and metastatic potentials of colorectal cancer (Toiyama 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • putatively binding integrins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in renal cell carcinoma
    tumoral     --over  
    in colon carcinoma (Toiyama 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS