Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TTLL2 contributors: mct - updated : 04-01-2012
HGNC name tubulin tyrosine ligase-like family, member 2
HGNC id 21211
Location 6q27      Physical location : 167.738.573 - 167.756.177
Synonym name
  • NYD-TSPG protein
  • chromosome 6 open reading frame 104
    • Synonym symbol(s) C6orf104, NYD-TSPG, BCP-41
    DNA
    TYPE functioning gene
    STRUCTURE 17.60 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2877 - 592 - 2000 11054573
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver   moderately Homo sapiens
    Lymphoid/Immunethymus   moderately Homo sapiens
    Reproductivemale systemtestis  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one TTL domain
  • an approximately 40-AA F-box motif
    • HOMOLOGY
    interspecies homolog to murine LOC272661
    Homologene
    FAMILY tubulin tyrosine ligase-like family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • tubulinyl-tyrosine ligase activity
  • function in the protein modification of tubulin tyrosine ligation and may play a role in tumor cell regulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS