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FLASH GENE
Symbol TTI2 contributors: mct - updated : 05/12/2008
HGNC name TELO2 interacting protein 2
HGNC id 26262
Location 8p12      Physical location : -
Synonym name
  • chromosome 8 open reading frame 41
  • Tel two-interacting protein 2
  • Synonym symbol(s) FLJ23263, C8orf41
    DNA
    TYPE functioning gene
    STRUCTURE 14.68 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2394 57 508 - 2010 20801936
    8 - 2763 57 508 - 2010 20801936
    8 - 2516 - 508 - 2010 20801936
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Endocrineadrenal gland    
     neuroendocrinepituitary   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • TTI1 and TTI2 protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoints
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • exist in multiple complexes, including a 2-MDa complex with TELO2, called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TELO2-TTI1-TTI2 complex is a PIKK-specific cochaperone for HSP90AA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS