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FLASH GENE
Symbol TTI1 contributors: mct - updated : 11-09-2012
HGNC name . TELO2 interacting protein 1
HGNC id 29029
Location 20q11.23      Physical location : 36.611.424 - 36.661.833
Synonym name
  • KIAA0406
  • TEL2-interacting protein 1 homolog
  • Tel two interacting protein 1
  • smg-10 homolog, nonsense mediated mRNA decay factor
  • Synonym symbol(s) KIAA0406, smg-10
    DNA
    TYPE functioning gene
    STRUCTURE 50.41 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3931 122 1089 - 2010 20810650
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Gustatory (taste)tongue    
    Nervousbrain    
    Reproductivefemale systemuteruscervix  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to alpha 1 subunit
    homolog to calcium voltage-gated channel (VDCC)
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • calcium voltage-gated channel (VDCC)
  • TTI1 and TELO2 are important not only for MTOR stability but also for assembly of the MTOR complexes to maintain their activities
  • TTI1 and TTI2 protect cells from spontaneous DNA damage, and are required for the establishment of the intra-S and G2/M checkpoints
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • exist in multiple complexes, including a 2-MDa complex with TELO2, called the Triple T complex, and phosphoinositide-3-kinase-related protein kinases (PIKKs) such as ataxia telangiectasia-mutated (ATM)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to TELO2 in mammalian cells, and interacts with and stabilizes all six members of the PIKK family of proteins (MTOR, ATM, ATR, DNA-PKcs, SMG1, and TRRAP)
  • TELO2-TTI1-TTI2 complex is a PIKK-specific cochaperone for HSP90AA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS