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FLASH GENE
Symbol TTF2 contributors: - updated : 02-05-2006
HGNC name transcription termination factor, RNA polymerase II
HGNC id 12398
Location 1p22      Physical location : 117.602.948 - 117.645.489
Synonym name lodestar protein
Synonym symbol(s) HUF2
EC.number 3.6.1.-
DNA
TYPE functioning gene
STRUCTURE 42.00 kb     23 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D1S250 - NRAS - TSHB TSHB - D1S3540 - NGFB - CD58 - D1S3262 - D1S189 - IGSF2 - TTF2 - D1S3587 - MAN1A2 - D1S453 - WARS2 - D1S3292 - HSD3B1 - PHGDH PHGDH - HMGCS2 HMGCS2 - D1S514 - cen
Authors Chelala (01)
Physical map
AMPD1 1p13 adenosine monophosphate deaminase 1 (isoform M) NRAS 1p13.2 neuroblastoma RAS viral (v-ras) oncogene homolog D1S155E 1p22 NRAS-related gene FLJ21168 1p13.1 hypothetical protein FLJ21168 SYCP1 1p13 synaptonemal complex protein 1 TSHB 1p13 thyroid stimulating hormone, beta TSPAN-2 1p13.1 tetraspan 2 NGFB 1p13.1 nerve growth factor, beta polypeptide LOC391068 1 similar to mCAF1 protein VANGL1 1p11-p13.1 vang-like 1 (van gogh, Drosophila) LOC387624 1 hypothetical gene supported by NM_024062 CASQ2 1p13.3-p11 calsequestrin 2 (cardiac muscle) NHLH2 1p12-p11 nescient helix loop helix 2 LOC343019 1p12 similar to Hnrpa1 protein SLC22A15 1p12 solute carrier family 22 (organic cation transporter), member 15 FLJ38716 1p12 hypothetical protein FLJ38716 ATP1A1 1p13 ATPase, Na+/K+ transporting, alpha 1 polypeptide MGC16179 1p12 hypothetical protein MGC16179 LOC148766 1p12 hypothetical LOC148766 CD58 1p13 CD58 antigen, (lymphocyte function-associated antigen 3) IGSF3 1p13 immunoglobulin superfamily, member 3 LOC388667 1 LOC388667 LOC391069 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC339396 1p12 similar to neurofilament, heavy polypeptide 200kDa; Neurofilament, heavy polypeptide; neurofilament, heavy polypeptide (200kD) CD2 1p13.1 CD2 antigen (p50), sheep red blood cell receptor PTGFRN 1p13.1-q21.3 prostaglandin F2 receptor negative regulator IGSF2 1p13 immunoglobulin superfamily, member 2 TTF2 1p13.1 transcription termination factor, RNA polymerase II TRIM45 1q12-21 tripartite motif-containing 45 LOC391070 1 similar to 40S ribosomal protein S15a B7-H4 1p12 immune costimulatory protein B7-H4 MAN1A2 1p13.1 mannosidase, alpha, class 1A, member 2 FLJ20202 1p12 FLJ20202 protein LOC391071 1 similar to voltage-dependent anion channel 2 GDAP2 1q21.1 ganglioside induced differentiation associated protein 2 WDR3 1p13-p12 WD repeat domain 3 LOC391072 1 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC343492 1p12 similar to Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) TBX15 1p13 T-box 15 WARS2 1p13.3-p13.1 tryptophanyl tRNA synthetase 2 (mitochondrial) LOC343495 1p11.2 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) HAO2 1p13.3-p13.2 hydroxyacid oxidase 2 (long chain) HSD3B2 1p13.1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 LOC391073 1 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC391074 1 similar to 3 BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA 5-->4-ISOMERASE (3BETA-HSD)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland predominantly
 female systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven motifs found in helicases
  • seven additional motifs shared by SWI2/SNF2 family members
  • three conserved motifs
  • a nuclear localization signal (NLS)
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to rattus Ttf2
    ortholog to murine Ttf2
    Homologene
    FAMILY
  • DEAD-like helicase superfamily
  • SNF2/RAD54 helicase family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • cytoplasmic during interphase
  • relocating to the nucleus as cells enter mitosis
  • basic FUNCTION
  • exhibiting ATPase activity which requires double-strand DNA
  • acting as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template
  • may contribute to mitotic transcription repression
  • may also be involved in pre-mRNA splicing
  • CELLULAR PROCESS nucleotide, transcription, termination
    nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the spliceosome
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Zn2+
  • protein
  • CDC5L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS