Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

TTC7A

contributors: mct - updated : 08-12-2016

HGNC name	tetratricopeptide repeat domain 7A
HGNC id	19750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	GIDID gastrointestinal defects and immunodeficiency syndrome
Location	2p21      Physical location : 47.168.312 - 47.303.274
Synonym symbol(s)	KIAA1140, GIDID, MINAT, TTC7

DNA

TYPE	functioning gene
STRUCTURE	160.20 kb     21 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001288953 21 - 5166 NP_001275882 - 824 - 2005 15718100 NM_001288951 21 - 5247 NP_001275880 - 882 - 2005 15718100 NM_020458 20 - 5175 NP_065191 - 858 - 2005 15718100 NM_001288955 19 - 5017 NP_001275884 - 504 - 2005 15718100

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       moderately Homo sapiens   thymus         Homo sapiens Skin/Tegument skin       moderately Homo sapiens Urinary kidney       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

nine TPR repeats

HOMOLOGY

interspecies

ortholog to murine Ttc7

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION

important role in the development of immune system cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TMEM150A strongly reduces the association of TTC7 with the EFR3-PI4KA complex, without impairing the localization of PI4KA at the plasma membrane

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GIDID

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS