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FLASH GENE
Symbol TTC5 contributors: mct/npt - updated : 26-02-2009
HGNC name tetratricopeptide repeat domain 5
HGNC id 19274
Location 14q11.2      Physical location : 20.757.302 - 20.774.153
Synonym name
  • stress responsive activator of p300
  • TPR repeat protein 5
  • Synonym symbol(s) STRAP
    DNA
    TYPE functioning gene
    STRUCTURE 16.83 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1845 - - - Demonacos (2001)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal NES, nuclear export signal
  • a tandem array of six tetratricopeptide repeat motifs, functioning in the assembly of multiprotein complexes (Adams 2008)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear accumulation of Strap is necessary for DNA damage-dependent stabilization of protein
    basic FUNCTION
  • facilitates TP53 activity in response to stress, in part through its stress-responsive accumulation protein and interfering with the MDM2-dependent downregulation of TP53 (Demonacos 2001)
  • p300-interacting protein that is required for an effective TP53 response (Adams 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the TP53 co-activator complex, having an important function in regulating the cellular response to DNA damage (Adams 2008)
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with various components of the p53 co-activator complex, including JMY (Adams 2008)
    cell & other
    REGULATION
    Other phosphorylated by ATM kinase (phosphorylates TTC5 in response to DNA damage, and phosphorylation is required for protein stabilization) (Adams 2008)
    phosphorylated by CHEK2 (augments protein stability once TTC5 has attained a nuclear location) (Adams 2008)
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal NES, nuclear export signal
  • a tandem array of six tetratricopeptide repeat motifs, functioning in the assembly of multiprotein complexes (Adams 2008)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear accumulation of Strap is necessary for DNA damage-dependent stabilization of protein
    basic FUNCTION
  • facilitates TP53 activity in response to stress, in part through its stress-responsive accumulation protein and interfering with the MDM2-dependent downregulation of TP53 (Demonacos 2001)
  • p300-interacting protein that is required for an effective TP53 response (Adams 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the TP53 co-activator complex, having an important function in regulating the cellular response to DNA damage (Adams 2008)
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with various components of the p53 co-activator complex, including JMY (Adams 2008)
    cell & other
    REGULATION
    Other phosphorylated by ATM kinase (phosphorylates TTC5 in response to DNA damage, and phosphorylation is required for protein stabilization) (Adams 2008)
    phosphorylated by CHEK2 (augments protein stability once TTC5 has attained a nuclear location) (Adams 2008)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS