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FLASH GENE

Symbol

TTC26

contributors: mct - updated : 25-08-2017

HGNC name	tetratricopeptide repeat domain 26
HGNC id	21882

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q34      Physical location : 138.818.489 - 138.874.550
Synonym name	intraflagellar transport protein 56
Synonym symbol(s)	DYF13, IFT56, dyf-13

DNA

TYPE	functioning gene
STRUCTURE	58.24 kb

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001318333 18 - 4511 NP_001305262 - 414 - 2014 24596149 NM_001321740 18 - 4320 NP_001308669 - 544 - 2014 24596149 NM_024926 18 - 4350 NP_079202 - 554 - 2014 24596149 NM_001144920 17 - 4216 NP_001138392 - 487 - 2014 24596149 NM_001321741 16 - 4032 NP_001308670 - 448 - 2014 24596149 NM_001287512 15 - 3957 NP_001274441 - 423 - 2014 24596149 NM_001144923 17 - 4257 NP_001138395 - 523 - 2014 24596149 NM_001287513 18 - 4279 NP_001274442 - 449 - 2014 24596149 NM_001321742 9 - 1227 NP_001308671 - 271 - 2014 24596149

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Urinary kidney tubule collecting duct     Mus musculus Visual eye retina       Mus musculus

cells

System Cell Pubmed Species Stage Rna symbol Urinary tubular cell Mus musculus Visual cone photoreceptor Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C-Elegans dyf-13

Homologene

FAMILY

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome

basic FUNCTION	is likely required for normal development and differentiation in retina and pronephros
	is an intraflagellar transport protein required for transport of motility-related proteins into flagella
	is necessary for efficient coupling between the accumulation of GLI at the ciliary tip and its dissociation from SUFU
	role for TTC26 in IFTB complex integrity that is crucial for cilia structure and function and, ultimately, development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ARL13B interacts with the IFT46 -: TTC26 dimer of the intraflagellar transport (IFT)-B complex, which mediates anterograde ciliary protein trafficking
	ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-TTC26 as well as on its nuclear localization signal

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS