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FLASH GENE
Symbol TTC25 contributors: mct - updated : 20-09-2016
HGNC name tetratricopeptide repeat domain 25
HGNC id 25280
Corresponding disease
ICS37 immotile cilia syndrome 37
Location 17q21.2      Physical location : 40.086.887 - 40.117.666
Synonym symbol(s) CILD35, DKFZp434H0115
DNA
TYPE functioning gene
STRUCTURE 35.91 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2310 - 672 - 2016 27486780
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight tetratricopeptide (TPR) domains, known to be involved in multiprotein-complex formation
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • might play a role as a ciliogenesis factor
  • facilitates recruitment and/or attachment of these ODA-DC proteins to ciliary axonemes via interaction with CCDC114
  • might functionally link the intraflagellar transport (IFT) system to the outer dynein arms (ODAs)-docking complex and ODA HC machinery in motile cilia
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of the ODA-DC machinery
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RFX2 is essential for expression of several ciliogenic genes, including TTC25, which we show here is required for ciliogenesis, HH signaling, and left-right patterning
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS37
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ttc25-deficient mice revealed an absence of outer dynein arms (ODAs)