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FLASH GENE
Symbol TTC21A contributors: mct - updated : 15-05-2019
HGNC name tetratricopeptide repeat domain 21A
HGNC id 30761
Corresponding disease
SPGF37 spermatogenic failure 37
Location 3p22.2      Physical location : 39.149.151 - 39.180.394
Synonym name
  • TPR domain containing STI2
  • TPR repeat protein 21A
  • stress-inducible protein 2
  • testicular tissue protein Li 212
  • Synonym symbol(s) IFT139A, STI2, MGC70523, MGC156293, DKFZp686P18239
    DNA
    TYPE functioning gene
    STRUCTURE 31.35 kb
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4269 - 1320 - 2014 24564958
    27 - 4125 - 1272 - 2014 24564958
    29 - 4236 - 1321 - 2014 24564958
    29 - 4212 - 1313 - 2014 24564958
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • several tetratricopeptide repeat (TPR) domains that frequently exist in IFT proteins and seem important for ciliary function
  • HOMOLOGY
    Homologene
    FAMILY TPR family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • encodes an intraflagellar transport (IFT)-associated protein that possesses several tetratricopeptide repeat domains that perform functions crucial for ciliary function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is very likely an IFT component interacting with IFT proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF37
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • the motility and progressive motility of spermatozoa were significantly reduced in the Ttc21amut/mut male mice