Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

TTC19

contributors: mct - updated : 28-06-2022

HGNC name	tetratricopeptide repeat domain 19
HGNC id	26006

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CMP3D2 complex III mitochondrial deficiency 2 SCAR33 Spinocerebellar ataxia, autosomal recessive 33
Location	17p12      Physical location : 15.902.781 - 15.932.096
Synonym symbol(s)	FLJ20343, MGC138312, MGC19520, 2010204O13Rik, MC3DN2

DNA

TYPE	functioning gene
STRUCTURE	45.19 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017775 10 - 3505 - 501 - 2011 21278747 NM_001271420 10 - 3187 NP_001258349 - 273 - 2011 21278747

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive female system ovary     highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four TPR repeats

mono polymer

oligo

HOMOLOGY

Homologene

FAMILY

kinesin light chain family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome

basic FUNCTION	may play a role in organelle transport
	mitochondrial chaperone possibly involved in early step assembly of complex III

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

oligomeric complex composed of two heavy chains and two light chains

INTERACTION

DNA

RNA

small molecule

protein

interacting with ZFYVE26 (TTC19 in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis) (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMP3D2 , SCAR33

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS