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FLASH GENE
Symbol TTC19 contributors: mct - updated : 08-10-2011
HGNC name tetratricopeptide repeat domain 19
HGNC id 26006
Corresponding disease
CMP3D2 complex III mitochondrial deficiency 2
Location 17p12      Physical location : 15.902.781 - 15.932.096
Synonym symbol(s) FLJ20343, MGC138312, MGC19520
DNA
TYPE functioning gene
STRUCTURE 30.03 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3505 - 501 - 2011 21278747
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Reproductivefemale systemovary  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four TPR repeats
mono polymer oligo
HOMOLOGY
Homologene
FAMILY kinesin light chain family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
basic FUNCTION
  • may play a role in organelle transport
  • mitochondrial chaperone possibly involved in early step assembly of complex III
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component oligomeric complex composed of two heavy chains and two light chains
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ZFYVE26 (TTC19 in turn interacts with CHMP4B, an endosomal sorting complex required for transport (ESCRT)-III subunit implicated in the abscission step of cytokinesis) (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS