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FLASH GENE
Symbol TTC14 contributors: KTN/npt - updated : 12-02-2009
HGNC name tetratricopeptide repeat domain 14
HGNC id 24697
Location 3q26.33      Physical location : 180.319.917 - 180.328.917
Synonym name TPR repeat protein 14
Synonym symbol(s) FLJ00166, KIAA1980, DRDL5813, PRO19630, DKFZp313M1015
DNA
TYPE functioning gene
STRUCTURE 8.97 kb     13 Exon(s)
MAPPING cloned Y linked N status confirmed
Map cen - D3S3565 - D3S3603 - TTC14 - D3S3662 - qter
Authors UCSC (2009)
Physical map
WIG1 3q26.3-q27 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) PIK3CA 3q26.3 phosphoinositide-3-kinase, catalytic, alpha polypeptide KCNMB3 3q26.3-q27.1 potassium large conductance calcium-activated channel, subfamily M beta member 3 ANC_2H01 3q27.1 zinc finger protein ANC_2H01 MFN1 3q27.1 mitofusin 1 GNB4 21q22.3 guanine nucleotide binding protein (G protein), beta polypeptide 4 BAF53A 3q27.1 guanine nucleotide binding protein (G protein), beta polypeptide 4 MRPL47 3q27.1 mitochondrial ribosomal protein L47 NDUFB5 3q27.1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa USP13 3q26.2-q26.3 ubiquitin specific protease 13 (isopeptidase T-3) PEX5R 3q27.1 Pex5p-related protein LOC391593 3 similar to Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) LOC131054 3q27.2 similar to RalA binding protein 1 (RalBP1) (Ral interacting protein 1) (76-kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) TTC14 3q27.2 tetratricopeptide repeat domain 14 DKFZp434A128 3q27.2 hypothetical protein DKFZp434A128 LOC389178 3 similar to RING finger protein 13 LOC391594 3 similar to KIAA1552 protein LOC391595 3 similar to 60S ribosomal protein L32 FXR1 3q28 fragile X mental retardation, autosomal homolog 1 LOC131118 LOC391596 3 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) SOX2 3q26.3-q27 SRY (sex determining region Y)-box 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 splicing 3059 88.2 770 - Ota (2004)
10 splicing 4813 49.6 439 - Clark (2003)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemplacenta   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one S1 motif
  • four TPR motifs
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ttc14 (88.4 pc)
    homolog to rattus Ttc14 (87.4 pc)
    Homologene
    FAMILY
  • TPR superfamily
  • TTC14 family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS