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FLASH GENE
Symbol TSSC1 contributors: mct - updated : 14-11-2014
HGNC name tumor suppressing subtransferable candidate 1
HGNC id 12383
Location 2p25.3      Physical location : 3.192.740 - 3.381.653
Synonym name
  • tumor-suppressing STF cDNA 1 protein
  • tumor-suppressing subchromosomal transferable fragment candidate gene
    • 1 protein
    DNA
    TYPE functioning gene
    STRUCTURE 188.91 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • RUNX2 binding site on the TSSC1 promoter region
    • MAPPING cloned Y linked   status provisional
    Map see CD81
    regionally located close to HBB@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1732 - 387 - 1998 9925925
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Reproductivefemale systembreastmammary gland highly
     female systemuteruscervix highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		five WD repeats
    HOMOLOGY
    interspecies homolog to Drosophila
    intraspecies homolog to Rb associated protein p48
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potential role of TSSC1 in breast cancer cell metastasis
  • suppresses cell invasion
    • CELLULAR PROCESS nucleotide, chromatin organization
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RUNX2 induces bone osteolysis by transcriptional suppression of TSSC1 (transcriptionally suppresses TSSC1 expression)
  • TSSC1 is required for efficient recruitment of GARP (composed of ANG2, VPS52, VPS53 and VPS54 subunits) to the TGN
    • cell & other
    REGULATION
    repressed by RUNX2 (TSSC1 expression is negatively regulated by RUNX2 in breast cancer cells)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    interaction between RUNX2 and TSSC1 might represent a viable target for therapeutic intervention to inhibit bone metastasis
    ANIMAL & CELL MODELS