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FLASH GENE
Symbol TSPYL5 contributors: mct - updated : 08-03-2010
HGNC name TSPY-like 5
HGNC id 29367
Location 8q22.1      Physical location : 98.285.714 - 98.290.176
Synonym name
  • testis-specific Y-encoded-like protein 5
  • TSPY-like protein 5
    • Synonym symbol(s) KIAA1750
    DNA
    TYPE functioning gene
    STRUCTURE 4.47 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4478 - 417 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Reproductivemale systemtestis  moderately
    Visualeye   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Tspyl5 (73.8pc)
    homolog to rattus Tspyl5 (72.4pc)
    Homologene
    FAMILY
  • nucleosome assembly protein (NAP) family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • involved in nucleosome assembly
  • involved in cell growth and resistance to radiation via the regulation of p21 and PTEN/AKT pathway (Kim 2010)
  • suppressor of TP53 function through its interaction with USP7
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with ubiquitin-specific protease 7 (USP7), deubiquitylase for the TP53 tumour suppressor and TSPYL5 reduces the activity of USP7 towards TP53, resulting in increased TP53 ubiquitylation
    • cell & other
    REGULATION
    activated by by LH in the primate corpus luteum
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    inactivated by DNA hypermethylation(Jung 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • could be a putative epigenetic target gene in gastric cancers (Jung 2008)
    • ANIMAL & CELL MODELS