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FLASH GENE
Symbol TSPYL2 contributors: mct - updated : 08-10-2014
HGNC name testis-specific Y-encoded-like protein 2
HGNC id 24358
Location Xp11.22      Physical location : 53.111.541 - 53.117.728
Synonym name
  • differentially expressed nuclear TGFB1 target protein
  • cutaneous T-cell lymphoma-associated tumor antigen
  • cell division autoantigen 1
  • CASK-interacting nucleosome assembly protein
  • CTCL tumor antigen se20-4
  • TSPY-like 2
  • coilin interacting nuclear ATPase protein
  • Synonym symbol(s) SE20-4, CTCL, DENTT, CDA1, CINAP, TSPX, HRIHFB2216, RP1-290F12.2 NP79, SE204
    DNA
    TYPE functioning gene
    STRUCTURE 6.17 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text TSPYL2 and TAF9 mRNAs are translated from different ATG codons and use distinct reading frames, resulting in them having no identity in their respective protein sequences
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2833 - 693 - 2005 16079131
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensAdult
    Nervousneuron Homo sapiensFetal
    cell lineage
    cell lines non small cell lung cancer
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four potential nuclear localization signals (NLS)
  • two coiled-coils regions conserved 191AA domain identical to TSPY family
  • Walker motifs A and B
  • a conserved domain with TSPY1, designated as SET/NAP domain
  • C-terminal acidic domain, responsible of inhibitory effect of TSPX on the cyclin B1-CDK1 complex
  • HOMOLOGY
    Homologene
    FAMILY
  • nucleosome assembly protein (NAP) family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in negative regulation of DNA regulation
  • playing a role in negative regulation of cell cycle and growth
  • involved in regulation of signal transduction
  • represses the cyclin B1-CDK1 phosphorylation activity
  • could serve a normal function in modulating cell-cycle progression at the G(2)/M stage
  • is essential for the formation of canonical Cajal bodies (CBs), histone transcription, and cell viability
  • serves a biological role in maintaining the G1 checkpoint under stress condition (pMID: 21738728)
  • may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal Bodies (CBs), assembly and disassembly in the nucleus of human cells
  • nucleosome assembly protein
  • contributes to cognitive variability through regulating the expression of GRIN2A and GRIN2B
  • REST and TSPYL2 are regulators of TGFB1 signaling and cell-cycle arrest induced by TGFB1 requires both REST and TSPYL2
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding to ribosomal DNA
    RNA
    small molecule
    protein
  • TGFB1 (role in TGFB1 mediated inhibition of anchorage independent growth)
  • binds cyclin B and inhibits cell proliferation, suggesting a role in cell cycle regulation
  • directly interacts with coilin, a marker protein of Cajal Bodies (CBs), nuclear organelles involved in the maturation of small nuclear ribonucleoproteins
  • acts as a novel regulator of RPS14-HDM2-TP53 by regulating the interaction between RPS14 and HDM2 through the control of RPS14 NEDDylation
  • interacts with calmodulin-associated serine/threonine kinase, which is implicated in X-linked mental retardation
  • TSPYL2 regulated the expression of GRIN2A and GRIN2B
  • interaction between TSPYL2 and CREBBP, indicating that TSPYL2 may activate gene expression through binding CREBBP
  • cell & other
    REGULATION
    Other modulated by TGFB1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    retards cells at the same stage of the cell cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential anticancer drug target
    ANIMAL & CELL MODELS