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FLASH GENE
Symbol TSPAN9 contributors: mct - updated : 14-12-2022
HGNC name tetraspanin 9
HGNC id 21640
Location 12p13.33      Physical location : 3.186.520 - 3.395.729
Synonym name
  • transmembrane 4 superfamily member tetraspan NET-5
  • tetraspan NET-5
    • Synonym symbol(s) NET-5, PP1057, Tspan-9
    DNA
    TYPE functioning gene
    STRUCTURE 209.18 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 4338 26.8 239 - 2009 18799160
    8 - 4255 - 239 - 2009 18799160
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • four potential hydrophobic transmembrane domains
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Tspan9 (97.1pc)
    homolog to rattus Tspan9 (97.1pc)
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • may have a role in regulating platelet function in concert with other tetraspanins and their associated proteins (Protty 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSPAN9 plays a fine-tuning role in platelet activation by regulating GP6 membrane dynamics
  • EMILIN1 can synergistically boost the tumor suppressive effect of TSPAN9, which may be produced by promoting TSPAN9 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --low  
    hypomethylated in Triple-negative breast cancer (TNBC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • TSPAN9 may be used as a potential prognostic factor in gastric cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    membrane proteins TSPAN9 and EMILIN1 may represent novel therapeutic targets for the treatment of gastric cancer
    ANIMAL & CELL MODELS