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FLASH GENE
Symbol TSPAN8 contributors: mct - updated : 28-10-2010
HGNC name tetraspanin 8
HGNC id 11855
Location 12q21.1      Physical location : 71.518.876 - 71.551.779
Synonym name
  • tumor-associated antigen CO-029
  • transmembrane 4 superfamily member 3
  • Synonym symbol(s) CO-029, TM4SF3, tspan-8
    DNA
    TYPE functioning gene
    STRUCTURE 32.90 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text using alternate polyadenylation sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1159 26 237 - 1990 2395876
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     liver   moderately
     pancreas exocrine   moderately
     stomach   predominantly
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
  • pancreatic carcinomas
  • gastric carcinomas
  • colon carcinomas
  • rectal carcinomas
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES other
    STRUCTURE
    motifs/domains
  • four potential hydrophobic transmembrane domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Tm4sf3
    ortholog to rattus Tm4sf3
    homolog to xenopus tm4sf3-prov
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • might be involved in esophageal carcinoma metastasis )
  • contributed to a selective recruitment of proteins and mRNA into exosomes, including VCAM1 and ITGA4, which were implicated in exosome-endothelial cells binding and endothelial cellsinternalization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with integrins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    all forms of cirrhosis
    tumoral     --over  
    in esophageal carcinomas
    Susceptibility
  • to schizophrenia
  • to bipolar disorder (BPD)
  • Variant & Polymorphism SNP
  • nsSNP rs3763978 was associated with schizophrenia
  • upstream transcriptional control region however, rs4500567 is associated with BPD
  • Candidate gene
    Marker
    Therapy target
  • with ADAM12L, might be potential targets of esophageal carcinoma for anti-metastasis therapy
  • ANIMAL & CELL MODELS