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FLASH GENE
Symbol TSPAN5 contributors: mct - updated : 20-06-2018
HGNC name tetraspanin 5
HGNC id 17753
Location 4q23      Physical location : 99.391.518 - 99.579.812
Synonym name
  • tetraspan 5
  • tetraspan NET-4
  • tetraspan TM4SF
  • transmembrane 4 superfamily member 9
  • transmembrane 4 superfamily, member 8
  • Synonym symbol(s) TSPAN-5, NET-4, TM4SF9, 4930505M03Rik, 2810455A09Rik
    DNA
    TYPE functioning gene
    STRUCTURE 186.32 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1433 - 268 - 2000 10719184
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    cell lineage
    cell lines myeloid (MO7, HEL, KG1, NB4), lymphoid (HOON, JURKAT, MOLT4, CEM) cell lines, lung, squamous, colon, breast carcinomas, post-radic lung, embryonic lung fibroblasts, fibrosarcoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • four hydrophobic transmembrane (TM) domains
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Tm4sf9
    homolog to rattus LOC362048
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • TSPAN13, TSPAN5 have a reciprocal function during osteoclastogenesis, i.e., positive and negative regulation by TSPAN5 and TSPAN13, respectively
  • with others TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation
  • TSPAN5, TSPAN10 play a critical role in osteoclast formation, at least in part, by modulating Notch signaling pathway
  • functions as a tumour suppressor in stomach to control the tumour growth
  • TSPAN5 and TSPAN14 can compensate for each other in Notch signaling
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSPAN5 and TSPAN14 positively regulated ligand-induced ADAM10-dependent NOTCH1 signaling
  • endothelial TSPAN5- and TSPAN17-ADAM10 complexes may regulate inflammation by maintaining normal CDH5 expression and promoting T lymphocyte transmigration
  • TSPANC8s are required for ADAM10 trafficking from the endoplasmic reticulum and its enzymatic maturation
  • ADAM10 associates directly with all members (TSPAN5, TSPAN10, TSPAN14, TSPAN15, TSPAN17 and TSPAN33) of a subgroup of tetraspanins having eight cysteines in the large extracellular domain and referred to as TSPANC8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased in tubal pregnancy than that in intrauterine pregnancy and non-pregnancy
    tumoral     --low  
    in gastric cancer (GC) and closely associated with clinicopathological features including tumour size and TNM stage
    constitutional       gain of function
    TSPAN5 and TSPAN10, are up-regulated during osteoclast differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a prognostic biomarker for predicting outcome of GC patients
  • Therapy target
    ANIMAL & CELL MODELS