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FLASH GENE
Symbol TSPAN3 contributors: mct - updated : 17-09-2021
HGNC name tetraspanin 3
HGNC id 17752
Location 15q24.3      Physical location : 77.336.361 - 77.363.570
Synonym name
  • transmembrane 4 superfamily member 8
  • tetraspan 3
  • tetraspan TM4SF
  • tetraspanin TM4-A
    • Synonym symbol(s) TM4-A, TSPAN-3, TM4SF8, 1700055K04Rik
    EC.number 2.7.10.2
    DNA
    TYPE functioning gene
    STRUCTURE 25.18 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3871 - 253 - 2015 26212080
  • isoform 1
    • 6 - 3796 - 228 - 2015 26212080
  • isoform 2
    • 6 - 6156 - 189 - 2015 26212080
  • isoform 3
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Reproductivefemale systemuteruscervix  
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Tspan3 (96.8pc)
    homolog to rattus Tspan3 (96.8pc)
    Homologene
    FAMILY
  • tetraspanin (TM4SF) family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text expressed at the cell surface
    basic FUNCTION
  • regulates the proliferation and migration of oligodendrocytes
  • mediates signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • functions to regulate cell adhesion, migration, proliferation and differentiation (Todd 1998)
  • involved in up-regulation in CD19 B cells in chronic fatigue syndrome (Aspler 2008)
  • is an important regulator of aggressive leukemias and having a role in oncogenesis
  • TSPAN3 acts in concert with other tetraspanins as a stabilizing factor of active ADAM10, APP and the gamma-secretase complex at the plasma membrane and within the endocytic pathway
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CLDN11 and integrins
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in brains of Alzheimer´s disease (AD) patients
    Susceptibility to chronic fatigue syndrome (CFS) (Aspler 2008)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS