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FLASH GENE
Symbol TSPAN18 contributors: mct - updated : 31-01-2017
HGNC name tetraspanin 18
HGNC id 20660
Location 11p11.2      Physical location : 44.785.975 - 44.953.975
Synonym symbol(s) TSPAN
DNA
TYPE functioning gene
STRUCTURE 205.28 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 4242 - 248 - 2007 17192395
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Nervousbrain   moderately
Reproductivefemale systemovary  moderately
 female systemuterus  highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney   moderately
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY storage , unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,lysosome
basic FUNCTION
  • may be involved in the development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia (pMID: 27208512)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • post-translational regulation of CDH6 protein levels by TSPAN18 that must be relieved by a FOXD3-dependent mechanism in order for cranial neural crest cells to migrate
  • FOXD3 is crucial for initial downregulation of TSPAN18, but other factors subsequently impact TSPAN18 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS