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FLASH GENE
Symbol TSPAN17 contributors: mct/npt - updated : 26-06-2018
HGNC name tetraspanin 17
HGNC id 13594
Location 5q35.2      Physical location : 176.074.387 - 176.086.058
Synonym name
  • F-box only protein 23
  • gamma-hydroxybutyrate (GHB)receptor
  • transmembrane 4 superfamily member 17
  • tetraspan protein SB134
  • Synonym symbol(s) FBX23, FBXO23, TM4SF17, GHBR, MGC14859, MGC71255, Tspan-17
    EC.number 3.6.5.3
    DNA
    TYPE functioning gene
    STRUCTURE 11.67 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 2605 - 332 - 2017 28600292
    9 splicing 2596 - 329 - 2017 28600292
    9 splicing 2564 - 263 - 2017 28600292
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortexfrontal cortex 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a 40AA F-box motif
  • four potential hydrophobic transmembrane domains
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Tm4sf17 / Fbxo23
    homolog to drosophila Tsp26A
    homolog to C. elegans tsp-12
    Homologene
    FAMILY
  • F-box protein family
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acting as a ubiquitin-protein ligase
  • phosphorylating dependent ubiquination
  • mitotic regulator, inhibiting the anaphase promoting complex (cyclosome APC) and preventing mitotic exit in cytostatic factor (CSF) arrested eggs
  • with others TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of a E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1 bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • endothelial TSPAN5- and TSPAN17-ADAM10 complexes may regulate inflammation by maintaining normal CDH5 expression and promoting T lymphocyte transmigration
  • ADAM10 associates directly with all members (TSPAN5, TSPAN10, TSPAN14, TSPAN15, TSPAN17 and TSPAN33) of a subgroup of tetraspanins having eight cysteines in the large extracellular domain and referred to as TSPANC8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS