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FLASH GENE
Symbol TSPAN13 contributors: mct/npt - updated : 26-06-2018
HGNC name tetraspanin 13
HGNC id 21643
Location 7p21.1      Physical location : 16.793.350 - 16.824.159
Synonym name
  • tetraspan NET-6
  • transmembrane 4 superfamily member 13
  • transmembrane 4 superfamily member tetraspan NET-6
  • Synonym symbol(s) FLJ22934, NET-6, TM4SF13, Tspan-13
    DNA
    TYPE functioning gene
    STRUCTURE 30.81 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1912 - 204 - Huang (2007)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • four hydrophobic domains
  • HOMOLOGY
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • may represent a novel breast cancer suppressor gene (Huang 2005)
  • TSPAN13, TSPAN5 have a reciprocal function during osteoclastogenesis, i.e., positive and negative regulation by TSPAN5 and TSPAN13, respectively
  • may have an important role in the progression of prostate cancer (Arencibia 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in estrogen receptor-negative breast cancers, and expression was lowest in "basal-like" tumors (Huang 2005)
    tumoral     --over  
    in prostate cancer and its expression correlates with factors of favourable outcome (Arencibia 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS