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FLASH GENE

Symbol

TSPAN10

contributors: mct - updated : 15-04-2016

HGNC name	tetraspanin 10
HGNC id	29942

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.3      Physical location : 79.609.348 - 79.615.778
Synonym name	oculospanin
Synonym symbol(s)	OCSP, FLJ39607

DNA

TYPE	functioning gene
STRUCTURE	11.58 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001290212 4 - 1893 NP_001277141 - 393 - 2012 23091066 NM_031945 3 - 1659 NP_114151 - 355 - 2012 23091066

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin       predominantly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four potential transmembrane domains

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Ocsp

Homologene

FAMILY

tetraspanin (TM4SF) family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	with others TspanC8 tetraspanins have a conserved function in the regulation of ADAM10 trafficking and activity, thereby positively regulating Notch receptor activation
	TSPAN5, TSPAN10 play a critical role in osteoclast formation, at least in part, by modulating Notch signaling pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ADAM10 associates directly with all members (TSPAN5, TSPAN10, TSPAN14, TSPAN15, TSPAN17 and TSPAN33) of a subgroup of tetraspanins having eight cysteines in the large extracellular domain and referred to as TSPANC8

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS