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FLASH GENE
Symbol TSNAX contributors: mct/np - updated : 30-12-2015
HGNC name translin-associated factor X
HGNC id 12380
Location 1q42.2      Physical location : 231.664.398 - 231.702.267
Synonym name
  • testis-brain RNA-binding protein
  • translin-associated protein X
  • Synonym symbol(s) TRAX, TSNX
    DNA
    TYPE functioning gene
    STRUCTURE 37.87 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    motif repetitive sequence
    text structure DNA binding site
    MAPPING cloned Y linked N status provisional
    Map cen - TSNAX - DISC1- DISC2 - D1S251 - qter
    Authors Millar (00)
    Physical map
    FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751 RAB4A 1q42-q43 RAB4A, member RAS oncogene family SPHAR 1q42.11-q42.3 S-phase response (cyclin-related) LOC126731 1q42.13 LOC126731 ACTA1 1q42.13-q42.2 actin, alpha 1, skeletal muscle NUP133 1q42.13 nucleoporin 133kDa ABCB10 1q42 ATP-binding cassette, sub-family B (MDR/TAP), member 10 TAF5L 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa KIAA0133 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC391177 1 similar to HMG-1 LOC388752 1 LOC388752 GALNT2 1q41-q42 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) PGBD5 1q42.13 piggyBac transposable element derived 5 COG2 1q41 component of oligomeric golgi complex 2 AGT 1q42-q43 angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8) CAPN9 1q42.11-q42.3 calpain 9 (nCL-4) FLJ14525 1q42.13-q43 hypothetical protein FLJ14525 TTC13 1q42.2 tetratricopeptide repeat domain 13 ARV1 1q42.2 likely ortholog of yeast ARV1 MGC15887 1q42.2 hypothetical gene supported by BC009447 FLJ30430 1q42.2 hypothetical protein FLJ30430 DKFZp547B1713 1q42.2 hypothetical protein DKFZp547B1713 GNPAT 1q42.11-q42.3 glyceronephosphate O-acyltransferase EXOC8 1q42.2 exocyst complex component 8 DKFZP547N043 1q42.12-q43 hypothetical protein DKFZp547N043 EGLN1 1q42.1 egl nine homolog 1 (C. elegans) TSNAX 1q42.1 translin-associated factor X DISC1 1q42.1 disrupted in schizophrenia 1 SIPA1L2 1q42.2 signal-induced proliferation-associated 1 like 2 KIAA1383 1q42.2 KIAA1383 protein MGC13186 1q42.2 hypothetical protein MGC13186 FLJ11383 1q42.2 hypothetical protein FLJ11383 LOC148995 1q42.2 similar to 40S ribosomal protein S7 (S8) KIAA1804 1q42 mixed lineage kinase 4 KCNK1 1q42-q43 potassium channel, subfamily K, member 1 SLC35F3 1q42.3 solute carrier family 35, member F3
    RNA
    TRANSCRIPTS type messenger
    text four major transcripts and transcript resulting from an intergenic splicing TRAX-DISC1 (Millar)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2667 33 290 - 2002 12036294
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver    
    Nervousbrain    
    Reproductivemale systemprostate  moderately
     male systemtestis   
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • N terminal bipartite nuclear targeting sequence
  • heptad repeat of hydrophobic AAs(leucine zipper structure)
  • a functional nuclear localization signal
  • mono polymer heteromer , hexamer
    HOMOLOGY
    interspecies homolog to murine Tsnax
    intraspecies homolog to translin
    Homologene
    FAMILY translin family
    CATEGORY DNA associated , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localize in nuclei in meiotic pachytene spermatocytes and in the cytoplasm of subsequent meiotic and post-meiotic cells
  • is a cytosolic protein that can transit into the nucleus
  • basic FUNCTION
  • playing a role in TSN functions
  • playing a special role in spermatogenesis
  • TSN and TSNAX play a central and important role in eukaryotic cell biology
  • play roles in very important cellular processes such as DNA recombination, spatial and temporal expression of mRNA, and in siRNA processing
  • both translin and TSNAX are binding competent and contribute to the nucleic acid binding activity
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • TSN/TSNAX heteromultimers for modulation of DNA and RNA binding activity of translin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed in testis and interacting with SUN1, AKAP9, GOLGA3, TSNAXIP1
  • interaction with TSN (the subcellular locations of TSN and TSNAX in male germ cells are modulated by the relative ratios of TSNAX and TSN)
  • ADORA2A modulates the differentiation ability of trophic factors through a novel interacting protein, TRAX
  • interacting with ADORA2A (Zezula 2008)
  • TSNAX, localized in the cytosol and nucleus, competes with plasma-membrane bound GNAQ for PLCB1 binding thus stabilizing PLCB1 in other cellular compartments
  • novel role of PLCB1 in gene regulation through TSNAX association
  • cell & other
    REGULATION
    Other post-transcriptionally regulated by its partner protein TSN, and both are essential for normal cell proliferation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    translocation t(1;11) (q42.1;q14.3) in a family of patients affeced by schizophrenia
    constitutional   translocation    
    five speciesof intergenic splicing, one yielding a fusion protein TSNAX/DISC1
    tumoral fusion      
    chimeric TSNAX-DISC1 occurred significantly upregulated in multiple endometrial carcinoma samples
    Susceptibility
  • to bipolar spectrum disorder
  • to autism spectrum disorders
  • Variant & Polymorphism other
  • polymorphisms increasing the risk of bipolar spectrum disorder
  • deleted in autism spectrum disorders (Williams 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS