Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TSKS contributors: mct/npt - updated : 20-01-2009
Location 19q13.3      Physical location : 50.243.011 - 50.266.515
Genatlas name testis-specific kinase substrate
Synonym name testis specific serine/threonine kinase substrate
Synonym symbol(s) TSKS1
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 23.50 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1812 65.1 592 - Hao (2004)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide
  • several potential phosphorylation and glycosylation sites
  • HOMOLOGY
    interspecies homolog to murine Tsks
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • might play a role in sperm function (as other members of this family)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis and spermiogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TSSK2
  • capability of PPP1CC2 to form a complex with TSSK1B mediated by the direct interaction of each with the kinase substrate protein TSKS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in cancerous testicular tissue (seminoma, teratocarcinoma embryonal and Leydig cell tumors)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS