Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TSHZ1 contributors: mct - updated : 17-12-2011
HGNC name teashirt zinc finger homeobox 1
HGNC id 10669
Corresponding disease
CAUA congenital aural atresia
Location 18q22.3      Physical location : 72.922.730 - 73.001.900
Synonym name
  • serologically defined colon cancer antigen 33
  • teashirt family zinc finger 1
    • Synonym symbol(s) NYCO33, SDCCAG33, TSH1
    DNA
    TYPE functioning gene
    STRUCTURE 79.17 kb     2 Exon(s)
    text structure two exons, of which only exon 2 is coding
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4982 - 1032 - 2011 22152683
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart   highly
    Digestiveintestinelarge intestine   
     liver    
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cell lineage
    cell lines various cancer
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		zinc-finger domain
    HOMOLOGY
    interspecies homolog to murine Sdccag33
    Homologene
    FAMILY
  • teashirt C2H2-type zinc-finger protein family
    • CATEGORY transcription factor , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • potentially required for the development of the soft palate
  • developmental regulator protein
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text tumor antigen
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAUA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in juvenile angiofibroma in the posterior nasal cavity of adolescent males
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Tshz1(-/-) mice exhibited Hox-like vertebral malformations and homeotic transformations in the cervical and thoracic regions, suggesting that Tshz1 and Hox genes are involved in common pathways to control skeletal morphogenesis
  • Tshz1 inactivation in mice leads to neonatal lethality and causes multiple developmental abnormalities, including a severe middle-ear phenotype that mimics defects observed in individuals with isolated congenital aural atresia