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FLASH GENE
Symbol TSGA10 contributors: mct/npt - updated : 16-04-2021
HGNC name testis specific, 10
HGNC id 14927
Corresponding disease
SPGF26 spermatogenic failure 26
Location 2q11.2      Physical location : 99.613.724 - 99.771.187
Synonym name
  • testis development protein NYD-SP7
  • cancer/testis antigen 79
  • Synonym symbol(s) CEP4L, CT79, SPGF26
    DNA
    TYPE functioning gene
    STRUCTURE 157.71 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • Variants 1 and 2 encode the same protein
  • using two distinct promoters and splicing of exons 4 and 7 produced these transcript variants, which have the same coding sequence, but the sequence of 5'untanslated region (5'UTR) is different between them (PMID: 28739310)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3903 81.4 698 - 2010 20797700
    20 - 3793 81.4 698 - 2010 20797700
    17 - 3474 - 589 - 2010 20797700
    17 - 3473 - 589 - 2010 20797700
    18 - 3431 81.4 698 - 2010 20797700
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemtestis  highly Homo sapiens
    Respiratoryrespiratory tracttrachea  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • myosin tail
  • HOMOLOGY
    Homologene
    FAMILY
  • ezrin-radixin-moesin family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • tumour-associated antigen of cutaneous lymphoma
  • testis-expressed protein with a key role in spermatogenesis
  • TSGA10 could influence the function of antigen presenting cells (APC) via its interaction with cytoskeletal proteins such as vimentin
  • overexpression of TSGA10 would induce disruption of HIF1A axis and exert potent inhibitory effects on tumor angiogenesis and metastasis
  • is a cancer testis antigen involved in the process of spermatogenesis
  • potential role of TSGA10 5'UTR in regulation of translation in unusual environmental conditions like hypoxia
  • TSGA10 could be considered as a tumor suppressor in AML patients
  • overexpression of TSGA10, as a tumor suppressor gene, in endothelial cells resulted in decreased proliferation, migration and therefore, angiogenic activity of HUVECs
  • likely potent anti-angiogenesis activity of TSGA10 in HUVECs through down-regulation of ERK and AKT signalling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TSGA10 could bind EPAS1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF26
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinomas and bladder cancer
    tumoral     --over  
    could decrease the metastatic and metabolic activity of cancer cells through its inhibitory effect on HIF1 activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • target of immune reactions in autoimmune polyendocrine syndrome type I (PGA1)
  • could be considered in the research for therapeutic candidates in cancer
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    could be considered as a potent therapeutic candidate, prognostic factor and a cancer management tool
    ANIMAL & CELL MODELS