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FLASH GENE

Symbol

TSEN34

contributors: mct/npt - updated : 03-09-2009

HGNC name	tRNA splicing endonuclease 34 homolog (S. cerevisiae)
HGNC id	15506

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PCH2C pontocerebellar hypoplasia 2C
Location	19q13.42      Physical location : 54.694.118 - 54.698.394
Synonym name	leukocyte receptor cluster (LRC) member 5
	tRNA-intron endonuclease Sen34
Synonym symbol(s)	LRC5, HSEN34, LENG5, SEN34, SEN34L
EC.number	3.1.27.9

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	leukocyte receptor cluster
STRUCTURE	3.33 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024075 5 - 1368 NM_024075 33 310 - - NM_001077446 4 - 1371 NP_001070914 33 310 - Paushkin (2004)

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon   moderately   mouth gingiva       Endocrine neuroendocrine pituitary     highly Lymphoid/Immune tonsils       highly Nervous brain         Reproductive female system ovary     predominantly   female system uterus     moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage
cell lines
fluid/secretion	moderately in lymph

at STAGE

physiological period

fetal

Text	highly in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies	homolog to rattus TSEN34 (88.4 pc)
	homolog to murine Tsen34 (88 pc)

Homologene

FAMILY

tRNA-intron endonuclease family

CATEGORY

enzyme , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus
text	may be transiently localized in the nucleolus

basic FUNCTION	involved in the identification and the cleavage of the splice sites in pre-tRNA
	cleaving pre-tRNA at the 5' and 3' splice sites to release the intron
	also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituting one of the two catalytic subunit of the tRNA-splicing endonuclease complex
	heterotetramer composed of SEN2, SEN15, SEN34/LENG5 and
	SEN54
	tRNA splicing endonuclease complex also contains proteins of the Pre-mRNA 3' end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2

INTERACTION

DNA

RNA

small molecule

protein

associated with pre-mRNA 3' end processing factors

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PCH2C

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS