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FLASH GENE
Symbol TRUB1 contributors: mct - updated : 08-01-2019
HGNC name TruB pseudouridine (psi) synthase homolog 1 (E. coli)
HGNC id 16060
Location 10q25.3      Physical location : 116.697.951 - 116.737.438
Synonym symbol(s) PUS4
DNA
TYPE functioning gene
STRUCTURE 39.49 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
Physical map
FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein GFRA1 10q26 GDNF family receptor alpha 1 MGC35062 10q26.11-q26.12 Similar to RIKEN cDNA 1700011F14 gene LOC119548 10q26.12 hypothetical protein LOC119548 PNLIP 10q24-q26 pancreatic lipase PNLIPRP1 10q26.12 pancreatic lipase-related protein 1 PNLIPRP2 10q26.12 pancreatic lipase-related protein 2 MGC33547 10q26.12 hypothetical protein MGC33547 HSPA12A  heat shock 70kDa protein 12A LOC387712 10 similar to RIKEN cDNA 6430537H07 gene KIAA1598 10q26.12 KIAA1598 protein LOC387713 10 similar to ventral anterior homeobox 1 TRIK 10q26.12 TWIK-related spinal cord K+ channe SLC18A2 10q25 solute carrier family 18 (vesicular monoamine), member 2 LOC118987 10q26.12 hypothetical protein LOC118987
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 3412 - 349 - 2017 28073919
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VFAVHKPKGPTSA box in positions 71-83 corresponding to motif I of the TruB family (probably involved in conserving protein structure)
  • The TruB domain between W104 and I255 with another short motif, GGTLDS AARGVLVV, including the highly conserved D residue that characterizes motif II (involved in uridine recognition and in catalytic function of psi synthases).
  • HOMOLOGY
    interspecies ortholog to bacterial TruB/psi55
    Homologene
    FAMILY pseudouridine synthase TRUB family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
  • TRUB1 and PUS7 are the two key PUSs acting on mammalian mRNA and to computationally model the sequence and structural elements governing the specificity of TRUB1, achieving near-perfect prediction of its substrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS