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FLASH GENE
Symbol TRPV2 contributors: npt/ - updated : 04-09-2006
HGNC name transient receptor potential cation channel, subfamily V, member 2
HGNC id 18082
Location 17p11.2      Physical location : 16.318.855 - 16.340.315
Synonym name
  • vanilloid receptor-like
  • Osm-9-like TRP channel 2
  • Synonym symbol(s) VRL, OTRPC2, VRL-1, VRL1, MGC12549
    DNA
    TYPE functioning gene
    STRUCTURE 21.43 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC147151 17p11.2 hypothetical LOC147151 IL6STP 17p11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor) pseudogene MEIS3 17p11.1 Meis1, myeloid ecotropic viral integration site 1 homolog 3 (mouse) ADORA2B 17p11.2 adenosine A2b receptor FLJ20343 17p11.2 hypothetical protein FLJ20343 NCOR1 17-p11.2 nuclear receptor co-repressor 1 PIGL 17p12-p11.2 phosphatidylinositol glycan, class L p30 17p11.2 nuclear protein p30 UBB 17p12-p11.1 ubiquitin B TRPV2 17p11.2 transient receptor potential cation channel, subfamily V, member 2 MGC40157 17p11.2 hypothetical protein MGC40157 LOC388341 17 similar to Hypothetical protein LOC192976 ZNF287 17p11.2 zinc finger protein 287 LOC284045 17p11.2 hypothetical gene supported by NM_006275; BC006832; U30828; U30829; U30883 KIAA1349 17p11.2 KIAA1349 protein LOC390766 17 similar to Ribonuclease H1 (RNase H1) (Ribonuclease H type II) LOC147226 17p11.2 similar to yeast Upf3, variant A pseudogene LOC252841 17p11.2 signal recognition particle 68kD pseudogene LOC266619 17p11.2 nitric oxide synthase 2A (inducible, hepatocytes) pseudogene LOC353194 17p11.2 keratin pseudogene LOC388342 17 similar to Keratin, type I cytoskeletal 16 (Cytokeratin 16) (K16) (CK 16) LOC388343 17 similar to Keratin, type I cytoskeletal 14 (Cytokeratin 14) (K14) (CK 14) LOC147228 17p11.2 keratin pseudogene LOC339186 17p11.2 keratin pseudogene CLPSMCR 17p11.2 coactosin-like, Smith Magenis syndrome chromosome region LOC390768 17 similar to FLJ00050 protein LOC96597 17p11.2 hypothetical protein LOC96597 TNFRSF13B 17p11.2 tumor necrosis factor receptor superfamily, member 13B M-RIP 17p11.2 myosin phosphatase-Rho interacting protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2797 - 764 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three ankyrin repeats domain at the N terminal
  • six transmembrane domains
  • a putative pore-loop region between TM5 and TM6
  • a C terminal cytoplasmic tail
  • HOMOLOGY
    interspecies homolog to murine Vrl1
    Homologene
    FAMILY
  • transient receptor family
  • TRPV subfamily
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text translocates from the cytoplasm to the plasma membrane upon ligand stimulation
    basic FUNCTION
  • may be involved in transduction of high-temperature heat responses in sensory ganglia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text
  • ion transporter
  • heat-gated ion channel
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with a c-Amp-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ABCD3
  • cell & other
    REGULATION
    activated by high temperatures (higher than 52 degrees Celsius)
    Other not activated by capsaicin
    regulated, at least in part, by IGFI, PDGF and neuropeptide head activator
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS