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FLASH GENE
Symbol TRPM5 contributors: mct - updated : 10-12-2014
HGNC name transient receptor potential cation channel, subfamily M, member 5
HGNC id 14323
Location 11p15.5      Physical location : 2.425.747 - 2.444.275
Synonym name
  • melastatin (MLSN1) and TRP (transient receptor potential) related gene 1
  • MLSN1 and TRP-related
  • long transient receptor potential channel 5
    • Synonym symbol(s) LTRPC5, MTR1
    DNA
    TYPE functioning gene
    STRUCTURE 18.53 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - H19 - INS ,IGF2 - D11S1318 - CD81 - TSSC4 - TRPM5 - KCNQ1 - D11S724 - D11S679 - D11S648 - NAP1L4 - cen
    Text [PHLDA2 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 splicing 3913 131.45 1165 - 2003 14634208
    - splicing - 97.74 872 - 2003 14634208
    five transmembrane segments (5TM)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrinepancreas   highly Homo sapiens
    Nervousbrain     Homo sapiens
    Olfactory (smell)olfactory bulb     Homo sapiens
    Respiratorylung    
     nasopharynx   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...) Homo sapiens
    Olfactoryepithelial cell Homo sapiens
    cell lineage
    cell lines HeLa cells, Burkitt lymphoma cells
    fluid/secretion
    at STAGE
    physiological period fetal
    Text various tissues
    IMPRINTING maternally
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a TRP (EWK FHR) and a zinc finger containing alpha kinase domain
    • HOMOLOGY
    interspecies homolog to murine Trpm5
    intraspecies homolog to melastatin 1 (MLSN1)
    homolog to human TRPC7 (transient receptor potential channel ) gene 1
    homolog to TRPM4
    Homologene
    FAMILY
  • transient receptor family
  • LTrpC subfamily
  • subfamily M (melastatin)
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing an important role in gustatory tissue, activating the taste receptors by transient calcium cation channel
  • may couple intracellular Ca2+ release to electrical activity and subsequent cellular responses
  • is essential for the detection of bitter, sweet, and amino acid tastes
  • might be involved in cholecystokinin secretion stimulated by linoleic acid in an enteroendocrine cell line
  • cation channel involved in sweet taste transduction
  • cation channel expressed in beta-cells and proposed to be involved in coupling intracellular Ca(2+) release to electrical activity and cellular responses
  • acting as an indispensable regulator of insulin secretion
  • membrane voltage initiated by TRPM5 channels is required for ATP secretion during taste reception
  • is essential for fat taste
  • TRPM2, TRPM4 and TRPM5 control insulin secretion levels by sensing intracellular Ca2+ increase, NAD metabolites, or hormone receptor activation
  • thoroughly characterized as a critical component of taste signaling and recently has been implicated in insulin release
  • monovalent cation channel activated by intracellular Ca2+
  • contributes to glucose-induced electrical activity of the beta cell and positively influences glucose-induced insulin release and glucose homeostasis
  • TRPM4, and TRPM5, are non-selective cation channels that are activated by an increase in intracellular calcium
  • TRPM4 and TRPM5 are both N-linked glycosylated at a unique site and also suggest that TRPM4/5 glycosylation seems not to be involved in channel trafficking, but mainly in their functional regulation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phospholipase C
  • TRPM5 activation by ATP couples TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via a TLX2 to trigger MUC5AC secretion
    • cell & other
    REGULATION
    activated by heat
    inhibited by bitter compounds that constitutes the molecular basis of a novel mechanism of taste interactions, whereby the bitter tastant inhibits directly the sweet transduction pathway
    by physiological concentrations of Zn2+ through interaction with the pore-loop domain
    Other highly temperature-sensitive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    dysfunction of the TRPM5 protein could be an important factor in the etiology of some forms of type 2 diabetes, where disruption of the normal pattern of secretion is observed
    Susceptibility to diabetes mellitus
    Variant & Polymorphism other
  • common TRPM5 variants are likely to be associated with prediabetic phenotypes, and this may in turn contribute to the development of type 2 diabetes mellitus
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knockout of Trpm5 or Plcb2 selectively expressed in taste tissue, in mice abolished sweet, amino acid, and bitter taste reception, but did not affect sour or salty tastes
  • increased plasma insulin levels downregulate Trpm5 expression in pancreatic islets from leptin-deficient mouse models of type 2 diabetes