| basic FUNCTION
| transient receptor potential non voltage-channel, Ca2+-permeable nonselective cation channels important for neurite outgrowth and growth cone morphology of hippocampal neurons |
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non-specific cation channels activated through phospholipase C-dependent pathways  |
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having gating properties that can switch reversibly between voltage-dependent and voltage-independent states |
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activated via G protein-coupled neuronal receptors and has an essential function in innate fear |
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involved in the control of fear-related behaviors, both learned and innate |
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forms Ca2+-activated cation channels that are functionally coupled to Ca2+-selective ion channels through local Ca2+ increases beneath the plasma membrane |
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enriched in the brain, where it is believed to control neurite extension and growth cone morphology |
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TRPC4 and TRPC5 are implicated in important physiological functions, such as growth cone guidance and smooth muscle contraction |
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necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin–NFAT signaling pathway |
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important components of the mechanism controlling neurite extension and growth cone morphology |
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forms cationic channels either through homomultimeric assembly or heteromultimeric coordination with other TRPC proteins |
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calcium regulation by TRPC5 would play a key role as a switch between proliferation and neuronal differentiation from neural progenitor cells |
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TRPC5 and TRPC6 are antagonistic regulators of actin remodeling and cell motility in fibroblasts and kidney podocytes |
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TRPC5 and TRPC6 channels are now known as the Ca(2+) influx pathways for nonselective, cationic current in podocytes |
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potential TRPC5 function as an innocuous cold transducer in nociceptive and thermosensory nerve endings |
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specific role of TRPC5 in the innocuous range of cold temperature (37–25 °C) that is distinct from noxious cold sensing |
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essential function in the regulation of dendrite patterning in the mammalian brain |
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novel function for TRPC5 that couples calcium signaling to a ubiquitin ligase pathway at the centrosome and thereby orchestrates dendrite patterning and connectivity in the brain |
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TRPC1 and TRPC5 have critical roles in neurite outgrowth |
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suppression of neurite outgrowth by TRPC5 requires the channel function of TRPC5 |
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acts downstream of semaphorin signaling to cause changes in neuronal growth cone morphology and nervous system development |
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TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons |
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TRPC5 and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms |
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TRPC4 and TRPC5 proteins share 65p100 amino acid sequence identity and form Ca(2+)-permeable nonselective cation channels |
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Ca2+-permeable channel TRPC5 is an important determinant of albuminuria |
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receptor-operated cation channel, has been well recognized as a regulator in the central nervous system |
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functions of TRPC5 in regulating vascular aging |
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contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons |
