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FLASH GENE
Symbol TRPC1 contributors: mct/npt/pgu - updated : 22-01-2015
HGNC name transient receptor potential cation channel, subfamily C, member 1
HGNC id 12333
Location 3q23      Physical location : 142.443.265 - 142.526.727
Synonym name transient receptor potential canonical 1
Synonym symbol(s) TRP1, HTRP-1, MGC133334, MGC133335
DNA
TYPE functioning gene
STRUCTURE 83.46 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
text structure
  • TATA box and CCAAT sequence close to the transcription initiation site
  • four nuclear factor-kappaB (NF-kappaB)-binding sites in the 5'-regulatory region
    • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4179 91 793 - 1996 8646775
    long form
    12 - 4077 90 759 - 2009 19193631
    short form
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveliver    
    Nervousbrain   highly Homo sapiens
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarykidney    
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell
    Reproductivespermatocyte
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    physiological period fetal, pregnancy
    Text predominantly in brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytoplasmic N terminus
  • ankyrin repeats and a coiled coil structure
  • six transmembrane segments
  • a cytoplasmic C terminus with a dystrophin (coiled-coil) domain
  • a highly conserved TRP (EWKFHR) domain
    • conjugated GlycoP
    mono polymer homomer , heteromer , tetramer , heptamer
    HOMOLOGY
    interspecies ortholog to Drosophila store-operated channel (Soc)
    Homologene
    FAMILY
  • TRP superfamily of Ca2+ cation channels, classic subfamily
  • transient receptor family
  • STrpC subfamily
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • perisynaptic region of the cerebellar parallel fibre-purkinje cell synapse
  • mostly associated to the surface of spermatogenic cells
  • co-localizes and could be co-immunoprecipitated with beta-tubulin
  • forms functional endoplasmic reticulum (ER) homotetrameric channels, and is localized exclusively in the sarcoplasmic reticulum
    • basic FUNCTION
  • transient receptor potential non voltage-channel
  • involved in calcium homeostasis in megakaryocytes and platelets
  • plays fundamental roles in processes ranging from sensory physiology to male fertility
  • may influence flagellar movement
  • encoding a non-selective cation channel involved directly or indirectly in the regulation of cell volume
  • having a function in retinal epithelium cells, dependent on its interaction with beta-tubulin
  • showing a pattern of single-channel conductance, amiloride sensitivity and ion permeability distinct from that of TRPC1 alone
  • operates as a sarcoplasmic reticulum Ca2+ leak channel in skeletal muscle
  • deeply involved in intracellular Ca2+ homeostasis at rest and during muscle activation by potentially regulating SR Ca2+ content, resting cytosolic Ca2+ and kinetics of the voltage-evoked Ca2+ transients
  • necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin/NFAT signaling pathway
  • critical aspects of the TRPC1 channelosome that are involved in the regulation of TRPC1 function and TRPC1-SOC-generated Ca2+ signals
  • cationic channel with functional effects that include stimulation of cardiovascular remodelling
  • is potentially a molecular mediator for postsynaptic Ca2+ elevation required for BDNF-induced synaptic plasticity
  • TRPC1 and TRPC5 have critical roles in neurite outgrowth
  • acts as a scaffold at the cell surface to assemble a signaling complex to stimulate neurite outgrowth
  • both TRPC1 and TRPC4 are essential for an intrinsic membrane conductance mediating the plateau potential in lateral septal neurons, possibly as heteromeric channels
  • reduces calcium permeability in heteromeric channel complexes
  • TRPC1-mediated Ca2+ influx enhances PI3K/Akt pathway during muscle regeneration
  • regulates cell proliferation and motility, two processes underlying cancer progression
  • TRPC1-mediated increase in store-operated Ca2+ entry is required for the proliferation of adult hippocampal neural progenitor cells
  • down-regulation of TRPV6 currents by TRPC1 may increase the cellular diversity to fine-tune Ca2+ homeostasis
  • TRPC1 is able to suppress TRPV6 dependent currents/entry because of a reduction of TRPV6 plasma membrane expression
  • TRPC5 and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms
  • heteromeric TRPC3/TRPC1 could participate in regulating the resting cytosolic Ca(2+) levels in skeletal muscle
  • contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming with PKD2 a channel with a unique constellation of new and TRPP2/TRPC1-specific properties, activated in response to G-protein-coupled receptor activation
  • in glomerular mesangial cells, the TRPC1/TRPC4 complexes constitute the functional subunits of UBXN11 and the interaction between STIM1 and TRPC4 may be the mechanism for the activation of the channels
  • comprised of homo- or heterotetramers between either TRPC1/4/5
  • is a component of a Ca(2+)-dependent amplification of EGF-dependent cell proliferation
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOMER and ITPR1 (interaction TRPC1/ITPR1 regulated by HOMER)
  • interacting with C10orf63
  • interacting with STIM1
  • CAV1 interacts with TRPC1 and ITPR3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells
  • interacting with PKD2(form homotetramers, with distinct functional and regulatory properties, among which there are the presence of four subconductance states in PKD2)
  • binds directly to KL and KDR and strengthens the association to promote their cointernalization (
  • functional interaction of TRPC1 with TRPV6 that negatively regulates Ca2+ influx (
  • MARCKS coordinates native TRPC1 channel activation in VSMCs by acting as a reversible PI(4,5)P2 buffer, which is regulated by PRKCA-mediated TRPC1 phosphorylation
    • cell & other
    REGULATION
    activated by by depletion of intracellular Ca2+ stores (store-operated Ca2+ entry) or by stretch
    GRM1
    induced by TNF-alpha through an NF-kappaB-dependent pathway in endothelial cells, which can trigger augmented Ca2+ entry following Ca2+ store depletion
    Other stimulated by a G protein coupled receptor from extracellular space by a process called calcium capacitative entry (CCE)
    regulated by REST
    at least in certain cell types, TRPC1 is regulated during cell cycle progression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyepilepsy 
    TRPC channels could be an unsuspected but critical molecular target for clinical intervention for excitotoxicity
    ANIMAL & CELL MODELS