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FLASH GENE
Symbol TROAP contributors: mct/npt - updated : 22 -09-200
HGNC name trophinin associated protein (tastin)
HGNC id 12327
Location 12p13.12      Physical location : 49.716.970 - 49.725.513
Synonym name trophinin-assisting protein (tastin)
Synonym symbol(s) TASTIN
DNA
TYPE functioning gene
STRUCTURE 8.54 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 754 15.8 144 - Yang (2008)
15 - 2618 83.7 778 - Yang (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningendometrium  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text exclusively present on the apical side of the syncytiotrophoblast (Suzuki 1999)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY adhesion
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
basic FUNCTION
  • may be involved with bystin and trophinin in a cell adhesion molecule complex mediating an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation
  • playing an important role in cells by associating with the microtubular cytoskeleton
  • accessory protein for cell adhesion that participates in early embryo implantation (Yang 2008)
  • major function during mitosis is to maintain the structural and dynamic features of centrosomes, thereby contributing to spindle bipolarity (Yang 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associate with trophinin by presumably forming an active adhesion machinery (Aoki (2000)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS