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FLASH GENE
Symbol TRNAU1AP contributors: mct - updated : 25-10-2010
HGNC name tRNA selenocysteine 1 associated protein 1
HGNC id
Location 1p35.3      Physical location : 28.879.528 - 28.905.056
Synonym symbol(s) FLJ20503, PRO1902, RP4-669K10.4, SECP43, TRSPAP1
DNA
TYPE functioning gene
STRUCTURE 25.88 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1884 32.5 287 - 2005 16230358
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • RRM TRSPAP family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • RNA-binding protein, that associates specifically with mammalian selenocysteine tRNA (tRNA(Sec)
  • role of TRNAU1AP and SEPSECS in selenoprotein biosynthesis through interaction with tRNA([Ser]Sec) in a multiprotein complex
  • playing a role in regulation of selenoprotein expression by affecting the synthesis of Um34 on tRNA([Ser]Sec) and the intracellular location of SEPSECS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • multiple, coordinated protein-nucleic acid interactions between TRNAU1AP and the previously described selenoprotein cotranslational factors resulted in a model of selenocysteine biosynthesis and incorporation dependent upon both cytoplasmic and nuclear supramolecular complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS