basic FUNCTION
| required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon |
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putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations |
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may act as a modifier gene, modulating the phenotypic expression of the deafness-associated A1491G or C1409T mutation in mitochondrial 12 S rRNA |
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participates in the modification of mitochondrial tRNAs and is therefore important for mitochondrial translation |
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may modulate the phenotypic manifestation of deafness-associated mitochondrial mutation |
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participates in the modification of mitochondrial tRNAs and is therefore important for mitochondrial translation |
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not required for mitochondrial translation at normal steady-state levels of tRNAs, but it may possess an as yet uncharacterized function in another sulfur-trafficking pathway |
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might be involved in the assembly of enzyme complexes containing iron |
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sulfur clusters |
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tRNA methyltransferase that dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl methionine as the methyl group donor |