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FLASH GENE
Symbol TRMT10C contributors: 26022 - updated : 31-05-2018
HGNC name tRNA methyltransferase 10C, mitochondrial RNase P subunit
HGNC id
Corresponding disease
MRPP1D mitochondrial RNase P protein 1 deficiency
Location 3q12.3      Physical location : -
Synonym name
  • RNA (guanine-9-) methyltransferase domain containing 1
  • mitochondrial RNase P subunit 1
    • Synonym symbol(s) HNYA, MRPP1, RG9MTD1
    DNA
    TYPE functioning gene
    STRUCTURE 4.61 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1861 - 403 - 2008 18984158
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • is essential for transcript processing, RNA modification, translation and mitochondrial respiration
  • is important for the processing of the 5prime and 3prime transcript ends of three mitochondrial long noncoding RNAs (lncRNAs)
  • TRMT10C along with HSD17B10 and KIAA0391, form the mitochondrial ribonuclease P (mt-RNase P) complex that cleaves the 5prime ends of mt-tRNAs from polycistronic precursor transcripts
  • subunits TRMT10C and HSD17B10 form a subcomplex that binds conserved mitochondrial tRNA elements, including the anticodon loop, and positions the tRNA for methylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RNase P consists of three different proteins TRMT10C, MRPP2 (HSD17B10) and MRPP3 (PRORP), each of which is essential for RNase P function
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRMT10C and HSD17B10 both deliver the pre-tRNA substrate and activate KIAA0391 through an induced-fit process
  • presence of PRORP can enhance the methylation activity of TRMT10C/HSD17B10
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRPP1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS