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FLASH GENE
Symbol TRIT1 contributors: - updated : 28-04-2007
HGNC name tRNA isopentenyltransferase 1
HGNC id 20286
Location 1p35.3-p34.1      Physical location : 40.306.707 - 40.349.177
Synonym name tRNA isopentenylpyrophosphatetransferase
Synonym symbol(s) FLJ20061, MOD5, IPT, MGC149242, MGC149243, tRNA-IPT
EC.number 2.5.1.8
DNA
TYPE functioning gene
STRUCTURE 42.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Reproductivefemale systemuterus  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal mitochondrial targeting signal C2H2 zinc finger-like motif
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to yeast mod5
homolog to murine Trit1
Homologene
FAMILY IPP transferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • catalyses the addition of N6-isopentenyladenosine (i6A) on residue 37 of tRNA molecules that bind codons starting with uridine
  • candidate lung tumor suppressor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung adenocarcinomas as compared to normal lung tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS