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FLASH GENE
Symbol TRIP10 contributors: mct - updated : 10-09-2015
HGNC name thyroid hormone receptor interactor 10
HGNC id 12304
Location 19p13.3      Physical location : 6.739.706 - 6.751.528
Synonym name
  • CDC42 interacting protein
  • salt tolerator
  • Synonym symbol(s) CIP4, HSTP, STOT, STP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 11.84 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1782 - 593 - 2003 12456510
  • absence of an SH3 domain in Felic provides a structural basis for functional differences
  • 14 - 2029 - 545 highest expression in skeletal muscle 2003 12456510
    - - 2118 - 601 - 2003 12456510
    - - 2067 - 456 - 2003 12456510
    premature codon stop resulting in the loss of SH3 domain and truncated isoform
    - - - - - heart,lung trachea 2003 12456510
    retaining the SH3 domain
    15 - 2201 - 601 - 2003 12456510
    14 - 2062 - 593 - 2003 12456510
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Nervousbrain   highly Homo sapiens
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Rattus norvegicus
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal domain that bears resemblance to the non kinase domain of FER family
  • a BAR domain
  • SRC homology 3 domain at the C terminus
  • HOMOLOGY
    interspecies homolog to Xenopus Fyn and chicken Src
    Homologene
    FAMILY
  • Fes–CIP4 homology-Bin/Amphyphysin/Rvsp (F-BAR) family of proteins
  • CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton
    text
  • localizes to vesicles containing EGFR and RAB5A
  • F-BAR protein that localizes to membrane phospholipids
  • basic FUNCTION
  • regulating cytoskeletal organization through structural-functional differences in a tissue-specific manner
  • important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable MTOC (microtubule organizing center) polarization and NK cell cytotoxicity
  • critical for beta catenin-mediated cell-cell adhesion
  • implicated in promoting Epidermal Growth Factor Receptor (EGFR) internalization
  • implicated with FNBP1L in regulating late events in EGFR trafficking from endosomes that serves to limit sustained ERK activation within the endosomal compartment
  • level of its expression is associated with the maintenance and differentiation of mesenchymal stem cell lineage
  • important role in integrin-dependent T cell-dependent antibody responses and germinal center formation
  • involved in membrane deformation
  • essential for optimal germinal center formation, skin inflammation, and integrin-dependent T-cell migration
  • regulates cancer cell growth and death in a cancer type-specific manner
  • adaptor protein interacting with actin regulatory proteins and regulating endocytosis
  • suppressor of Src-induced invadopodia and invasion in breast tumor cells by promoting endocytosis of MMP14
  • plays a novel role in neuronal development by inhibiting neurite formation
  • functions in vesicle formation, endocytosis and membrane tubulation
  • is also involved in protrusion in some cell types, including cancer cells (lamellipodia and invadopodia) and neurons (ribbed lamellipodia and veils)
  • new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production
  • scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking
  • plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease
  • strong synergism between NOSTRIN and TRIP10 functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HD
  • interacting with CREBBP
  • links microtubules to WAS, and both molecules are important for the formation of podosomes
  • limits surface expression of transmembrane type I matrix metalloprotease (MMP14), by promoting MMP14 internalization
  • F-BAR protein that localizes to membrane phospholipids through its BAR domain and interacts with Wiskott-Aldrich Syndrome Protein (WAS) via its SRC homology 3 domain
  • cooperative functions of the two F-BAR proteins TRIP10 and NOSTRIN in the regulation of CDH1 in epithelial morphogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    CIP4-V variant may contribute to renal cell carcinoma,especially with regard to metastasis and invasiveness
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyimmunodeficiency 
    TRIP10 antagonists might be useful in treating T cell-mediated diseases by inhibiting the entry of effector T cells into target organs.
    ANIMAL & CELL MODELS
  • cortical neurons from Cip4-null mice initiate neurites twice as fast as controls