SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
| intracellular,cytoplasm,cytoskeleton
|
text
| localizes to vesicles containing EGFR and RAB5A |
|
F-BAR protein that localizes to membrane phospholipids |
basic FUNCTION
| regulating cytoskeletal organization through structural-functional differences in a tissue-specific manner |
|
important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable MTOC (microtubule organizing center) polarization and NK cell cytotoxicity |
|
critical for beta catenin-mediated cell-cell adhesion |
|
implicated in promoting Epidermal Growth Factor Receptor (EGFR) internalization |
|
implicated with FNBP1L in regulating late events in EGFR trafficking from endosomes that serves to limit sustained ERK activation within the endosomal compartment |
|
level of its expression is associated with the maintenance and differentiation of mesenchymal stem cell lineage |
|
important role in integrin-dependent T cell-dependent antibody responses and germinal center formation |
|
involved in membrane deformation |
|
essential for optimal germinal center formation, skin inflammation, and integrin-dependent T-cell migration |
|
regulates cancer cell growth and death in a cancer type-specific manner |
|
adaptor protein interacting with actin regulatory proteins and regulating endocytosis |
|
suppressor of Src-induced invadopodia and invasion in breast tumor cells by promoting endocytosis of MMP14 |
|
plays a novel role in neuronal development by inhibiting neurite formation |
|
functions in vesicle formation, endocytosis and membrane tubulation |
|
is also involved in protrusion in some cell types, including cancer cells (lamellipodia and invadopodia) and neurons (ribbed lamellipodia and veils) |
|
new component in the highly coordinated system of megakaryocytic membrane and cytoskeletal remodeling affecting platelet production |
|
scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking |
|
plays a significant role in the intracellular hypertrophic signal transduction network that controls the growth of cardiac myocytes in heart disease |
|
strong synergism between NOSTRIN and TRIP10 functions |