Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM9 contributors: mct - updated : 02-02-2009
HGNC name tripartite motif-containing 9
HGNC id 16288
Location 14q22.1      Physical location : 51.441.981 - 51.562.422
Synonym name
  • homolog of rat RING finger Spring
  • RING finger protein 91
    • Synonym symbol(s) SPRING, KIAA0282, RNF91
    DNA
    TYPE functioning gene
    STRUCTURE 120.07 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D14S984 - D14S1031 - TRIM9 - D14S978 - D14S1018 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 4946 79 710 - Reymond
    7 splicing 4393 61.2 550 - Reymond
  • using an alternate splice site, resulting in a frameshift and an earlier stop codon as compared to variant 1
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal RING zinc finger
  • two B box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a COS (C-terminal subgroup one signature) domain
  • a FN3 (fibronectin type-3) domain
  • a C terminal B30-2/SPRY domain
  • RFP-like domain
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Trim9 (97.8 pc)
    homolog to murine Trim9 (97.1 pc)
    Homologene
    FAMILY
  • B box family, RBCC (TRIM family)
  • C-I TRIM family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • cytoplasmic bodies
  • in cytoplasmic speckles
    • basic FUNCTION
  • may act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with SNAP25
  • interactions between TRIM9 and UBE2G2 (TRIM E3 activity is only manifest with the UBE2 with which they interact)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS