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FLASH GENE
Symbol TRIM8 contributors: mct/pgu - updated : 06-02-2013
HGNC name tripartite motif-containing 8
HGNC id 15579
Location 10q24.32      Physical location : 104.404.251 - 104.418.076
Synonym name
  • ring finger protein 27
  • glioblastoma expressed ring finger protein
  • Synonym symbol(s) GERP, RNF27
    DNA
    TYPE functioning gene
    STRUCTURE 13.83 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D10S1697 - D10S1267 - TRIM8 - D10S1692 - D10S1738 - qter
    Authors UCSC (2009)
    Physical map
    FGF8 10q24 fibroblast growth factor 8 (androgen-induced) NPM3 10q24.31 nucleophosmin/nucleoplasmin, 3 MGEA5 10q24.1-q24.3 meningioma expressed antigen 5 (hyaluronidase) KCNIP2 10q24 Kv channel interacting protein 2 FLJ13114 10q24.32 hypothetical protein FLJ13114 HPS6 10q24.32 hypothetical protein FLJ13114 LDB1 10q24-q25 LIM domain binding 1 PRC 10q24.32 PGC-1 related co-activator NOLC1 10q22-q25 nucleolar and coiled-body phosphoprotein 1 ELOVL3 10q24.32 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 PITX3 10q25 paired-like homeodomain transcription factor 3 GBF1 10q24 golgi-specific brefeldin A resistance factor 1 NFKB2 10q24 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) PSD 10q24 pleckstrin and Sec7 domain protein MGC11279 10q24.32 hypothetical protein MGC11279 MGC2491 FLJ14280 10q24.32 hypothetical protein FLJ14280 FLJ22529 10q24.32-q24.33 hypothetical protein FLJ22529 ACTR1A 10q24 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) SUFU 10q24.32 suppressor of fused homolog (Drosophila) TRIM8 10q24.3 tripartite motif-containing 8 ARL3 10q24.1 ADP-ribosylation factor-like 3 SFXN2 10q24.32 sideroflexin 2 C10orf26 10q24.33 chromosome 10 open reading frame 26 CYP17A1 10q24.3 cytochrome P450, family 17, subfamily A, polypeptide 1 LOC390000 10 similar to Tebp-pending-prov protein C10orf32 10q24.33 chromosome 10 open reading frame 32 CYT19 10q24.33 Cyt19 protein CNNM2 10q24.32 cyclin M2 NT5C2 10q24.32 5'-nucleotidase, cytosolic II LOC90470 10q24.33 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) INA 10q24.33 internexin neuronal intermediate filament protein, alpha RNF134 10q24.33 ring finger protein 134 TAF5 10q24 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa MGC14697 10q24.33 upregulated during skeletal muscle growth 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2753 61.4 551 - 2004 15345195
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestine   lowly
     liver   lowly
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Nervousneuron
    cell lineage
    cell lines oligodendroglioma (anaplastic)
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING finger motif
  • two B-boxes (one type 1 and one type 2)
  • a coiled-coil domain (RBCC), the so called tripartite motif (TRIM) and a proline-rich C terminus
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Trim8 (97.3 pc)
    homolog to rattus Trim8 (97.8 pc)
    Homologene
    FAMILY
  • B box family, RBCC (tripartite motif (TRIM) family)
  • C-V TRIM family
  • RING family ubiquitin ligase
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • may be a regulator of SOCS-1 function
  • acting as a E3 ubiquitin ligase
  • modulates translocation of phosphorylated STAT3 into the nucleus through interaction with HSP90AB1 and consequently regulates transcription of NANOG in embryonic stem cells
  • positive regulator of TNF and interleukin-1beta (IL1B)–triggered NFKB activation
  • required for TNF- and IL1B–triggered NFKB activation and induction of inflammatory proteins
  • positively regulates TNF induced NFKB pathway
  • also enhanced the clonogenic and migration ability of cells by modulating NFKB
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with SOCS1
  • interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL6-dependent activation of STAT3
  • interacted with MAP3K7, a serine/threonine kinase essential for TNF- and IL1B–induced NFKB activation
  • physically interacted with TP53, impairing its interaction with MDM2
  • its ubiquitin ligase activity is essential for regulation of NFKB activation in both cytoplasm as well as nucleus
  • cell & other
    REGULATION
    induced by by interferon-gamma in epithelial and lymphoid cells
    LPS
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS