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FLASH GENE
Symbol TRIM71 contributors: mct - updated : 09-11-2017
HGNC name tripartite motif-containing 71
HGNC id 32669
Location 3p22.3      Physical location : 32.859.509 - 32.933.770
Synonym name
  • abnormal cell LINeage LIN-41
  • homolog of C. elegans Lin-41
  • Synonym symbol(s) LIN41, LIN-41
    EC.number 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 79.81 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D3S3727 - D3S3567 - TRIM71 - D3S3518 - D3S1619 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 5694 93.3 868 - 2014 24602972
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal RING finger motif of TRIM71 is critical for protein-protein interactions and polyubiquitination of LIN28B
  • two B-box domains (one type 1 and one type 2)
  • a coiled-coil domain
  • a FIL (filamin-type) domain
  • a NHL domain
  • HOMOLOGY
    interspecies homolog to rattus Trim71 (94.9 pc)
    homolog to murine Trim71 (93.7 pc)
    ortholog to zebrafish lin-41
    Homologene
    FAMILY
  • C-VII TRIM family
  • TRIM/RBCC family
  • TRIM-NHL family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • TRIM71 is a factor that facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal
  • localization to P-bodies
  • basic FUNCTION
  • playing an important role in development (Lin 2007)
  • TRIM71 is a factor that facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal
  • E3 ubiquitin ligases, TRIM25 and TRIM71 are validated as RNA-binding proteins (RBPs), revealing a potential link between RNA biology and protein-modification pathways
  • is not involved in regulatory networks of pluripotency but regulates neural differentiation
  • is critical for the regulation of TP53 functions in cell fate specification and survival during early brain development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • associates with AGO2 and microRNAs, and represses expression of CDKN1A, a cyclin-dependent kinase inhibitor that negatively regulates the G1-S transition
  • interaction with LIN28B through C-terminal unique ~50 amino acid stretch of LIN28B that is essential for TRIM71 interactions and subsequent polyubiquitination
  • interacts with TP53, controls its abundance by ubiquitination and antagonizes TP53-dependent pro-apoptotic and pro-differentiation response
  • cell & other
    REGULATION
    repressed by hsa-let-7a and hsa-let-7c (Lin 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lin41-deficient mice display neural tube closure defects
  • loss of Trim71 in mES cells leaves stemness and self-maintenance of these cells intact, but many genes required for neural development are up-regulated at the same time