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FLASH GENE
Symbol TRIM7 contributors: KTN/npt - updated : 10-02-2009
HGNC name tripartite motif-containing 7
HGNC id 16278
Location 5q35.3      Physical location : 180.620.923 - 180.632.177
Synonym name
  • glycogenin-interacting protein
  • RING finger protein 90
  • Synonym symbol(s) GNIP, RNF90
    DNA
    TYPE functioning gene
    STRUCTURE 11.25 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S408 - D5S2006 - TRIM7 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2862 56.5 511 widely distributed in tissues Skurat (2002), Zhai (2004)
    2 splicing 1114 23.6 221 - Reymond (2001), Skurat (2002)
  • lacking several 3' exons compared to variant 1
  • 5 splicing 3026 37 329 widely distributed in tissues Skurat (2002), Zhai (2004)
  • lacking two 5' exons compared to variant 1
  • 7 splicing 2869 34.1 303 widely distributed in tissues Skurat (2002), Zhai (2004)
  • having an alternate 5' exon
  • using a downstream in-frame start codon compared to variant 1
  • 7 splicing 2592 34.1 303 - Skurat (2002)
  • having an alternate 5' exon
  • using a downstream in-frame start codon compared to variant 1
  • 7 splicing 2660 34.1 303 - Skurat (2002)
  • having an alternate 5' exon and an additional segment compared to variant 1
  • using a downstream in-frame start codon compared to isoform 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon  
     pancreas exocrine   lowly
    Nervousbrain   lowly
    Reproductivefemale systemplacenta   
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C-terminal B30.2/SPRY domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Trim7 (84.9 pc)
    homolog to rattus Trim7 (88 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family domain
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • potentially involved in the initiation of glycogen biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a complex with glycogenin (GYG1, GYG2) and glycogenin synthase (GYS1, GYS2)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting DES
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS