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FLASH GENE
Symbol TRIM7 contributors: KTN/npt - updated : 10-02-2009
HGNC name tripartite motif-containing 7
HGNC id 16278
Location 5q35.3      Physical location : 180.620.923 - 180.632.177
Synonym name
  • glycogenin-interacting protein
  • RING finger protein 90
  • Synonym symbol(s) GNIP, RNF90
    DNA
    TYPE functioning gene
    STRUCTURE 11.25 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D5S408 - D5S2006 - TRIM7 - qter
    Authors UCSC (2009)
    Physical map
    LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2 KIAA1194 5q35.3 Homo sapiens KIAA1194 (KIAA1194), mRNA. SCGB3A1 5q35-qter secretoglobin, family 3A, member 1 FLT4 5q35.3 fms-related tyrosine kinase 4 LOC134082 5q35.3 similar to seven transmembrane helix receptor LOC134083 5q35.3 similar to Olfactory receptor 2Y1 MGAT1 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase FLJ21458 5q35.3 hypothetical protein FLJ21458 LOC391861 5 similar to cAMP-regulated phosphoprotein 19 (ARPP-19) BTNL3 5q35 butyrophilin-like 3 FLJ32535 5q35.3 butyrophilin 3 FOXO1B 5q35.2-q35.3 forkhead box O1B LOC340050 5q35.3 similar to hypothetical protein LOC340052 5q35.3 similar to seven transmembrane helix receptor LOC285659 5q35.3 similar to Olfactory receptor 2V3 LOC389353 5 LOC389353 TRIM7 5q35.3 tripartite motif-containing 7 TRIM41 5q35.3 tripartite motif-containing 41 GNB2L1 5q35.3-qter guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 FLJ23053 5q35.3 hypothetical protein FLJ23053 TRIM52 5q35.3 tripartite motif-containing 52 LOC389354 5 hypothetical gene supported by AL137733 LOC389355 5 similar to bA476I15.3 (novel protein similar to septin) LOC391862 5 similar to Olfactory receptor 4F3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2862 56.5 511 widely distributed in tissues Skurat (2002), Zhai (2004)
    2 splicing 1114 23.6 221 - Reymond (2001), Skurat (2002)
  • lacking several 3' exons compared to variant 1
  • 5 splicing 3026 37 329 widely distributed in tissues Skurat (2002), Zhai (2004)
  • lacking two 5' exons compared to variant 1
  • 7 splicing 2869 34.1 303 widely distributed in tissues Skurat (2002), Zhai (2004)
  • having an alternate 5' exon
  • using a downstream in-frame start codon compared to variant 1
  • 7 splicing 2592 34.1 303 - Skurat (2002)
  • having an alternate 5' exon
  • using a downstream in-frame start codon compared to variant 1
  • 7 splicing 2660 34.1 303 - Skurat (2002)
  • having an alternate 5' exon and an additional segment compared to variant 1
  • using a downstream in-frame start codon compared to isoform 1
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon  
     pancreas exocrine   lowly
    Nervousbrain   lowly
    Reproductivefemale systemplacenta   
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal RING zinc finger
  • a B-box domain
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C-terminal B30.2/SPRY domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Trim7 (84.9 pc)
    homolog to rattus Trim7 (88 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family domain
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • potentially involved in the initiation of glycogen biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • a complex with glycogenin (GYG1, GYG2) and glycogenin synthase (GYS1, GYS2)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting DES
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS