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FLASH GENE
Symbol TRIM69 contributors: mct - updated : 24-04-2013
HGNC name tripartite motif-containing 69
HGNC id 17857
Location 15q21.1      Physical location : 45.028.559 - 45.060.025
Synonym name
  • trimless
  • ring finger protein 36
  • RFP-like domain-containing protein trimless
  • testis-specific ring finger
  • Synonym symbol(s) Trif, RNF36, HSD34, TRIMLESS
    DNA
    TYPE functioning gene
    STRUCTURE 31.47 kb     7 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1911 57.3 500 - 2008 18836477
    6 splicing 1434 39.1 341 - 2008 18836477
  • lacking an alternate in-frame exon compared to variant a
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     mouth   highly
    Endocrineadrenal gland   moderately
    Hearing/Equilibriumearinnercochlea moderately
    Lymphoid/Immunelymph node    
    Nervousnervecranial nerve  predominantly
    Reproductivefemale systemuterus  moderately
     male systemtestis  moderately Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   moderately
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Mus musculusAdult
    Reproductivespermatid Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal RING-type zinc finger motif, with 82 amino acids, a RING-consensus sequence rich in cysteine residues between amino acid 41 and 81, essential for TRIM69 localisation and aggregation
  • one or two B-boxe
  • a B30.2 domain
  • an associated coiled-coil region
  • a C terminal SPRY (SP-1a and Ryanodine receptor) domain
  • conjugated PhosphoP , MetalloP
    HOMOLOGY
    interspecies homolog to rattus Trim69 (80 pc)
    homolog to murine Trim69 (78.6 pc)
    Homologene
    FAMILY
  • C-IV TRIM family
  • RING-B-box-coiled-coil (RBCC) family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    text
  • nuclear localization is under the control of phosphorylation, which might be mediated by p38
  • localise in both the cytoplasm and the nucleus in a speckled aggregating pattern
  • basic FUNCTION
  • inducing cell apoptosis when overexpressed
  • may play a role in germ cell homeostasis during spermatogenesis
  • could mediate ubiquitination, which could be enhanced by a proteasome inhibitor
  • novel E3 ubiquitin ligase identified from testis and may function to ubiquitinate its particular substrates during spermatogenesis
  • displayed an E3 ubiquitin ligase activity in a RING finger domain-dependent manner
  • possesses an E3 ligase activity and might mediate the formation of multiubiquitinylated products
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • colocalizes and interacts with PML (may interact with PML and induce cell apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS