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FLASH GENE
Symbol TRIM68 contributors: npt - updated : 06-02-2009
HGNC name tripartite motif-containing 68
HGNC id 21161
Location 11p15.4      Physical location : 4.619.901 - 4.629.437
Synonym name
  • SSA protein SS-56
  • Ro/SSA1 related protein
  • ring finger protein 137
    • Synonym symbol(s) SS-56, RNF137, FLJ10369, MGC126176
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.54 kb     7 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map pter - TRIM68 - D11S1758 - D11S4181 - cen
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3321 56.1 485 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    cell lineage
    cell lines many cancer cell lines, differentially expressed in androgen-dependent, androgen independent prostate cancer cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING-type zinc finger
  • a B-box type zinc finger
  • a coiled-coil domain
  • a B30.2/SPRY domain
    • HOMOLOGY
    interspecies homolog to murine Trim68 (77.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role of autoantigen in systemic lupus erythematosus and primary Sjoegren syndrome (Billaut-Mulot 2001, Ozato 2008)
  • being a putative E3 ubiquitin ligase (Miyajima 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • interacting with androgen receptor (Miyajima 2008)
    • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • being a potentially therapeutic target for prostate cancer (Miyajima 2008)
    • ANIMAL & CELL MODELS