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FLASH GENE
Symbol TRIM65 contributors: mct - updated : 21-11-2018
HGNC name tripartite motif-containing 65
HGNC id 27316
Location 17q25.1      Physical location : 73.885.041 - 73.893.054
Synonym symbol(s) 4732463G12Rik
DNA
TYPE functioning gene
STRUCTURE 8.01 kb     6 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3459 57.2 517 - 2018 28754688
5 - 3393 - 495 - 2018 28754688
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   moderately
Lymphoid/Immunetonsils   predominantly
Reproductivemale systemprostate  moderately
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a B box-type zinc finger
  • a B30.2/SPRY domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • TRIM65 is an ubiquitin E3 ligase for TNRC6 proteins
  • is an important protein involved in white matter lesion
  • TRIM65 functions as an oncogene in hepatocellular carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRIM65 interacts and colocalizes with trinucleotide repeat containing six (TNRC6) proteins in processing body-like structures
  • TP53 is required, at least in part, for TRIM65 function
  • TRIM65 as an essential component for the IFIH1 signaling pathway and provide physiological evidence showing that ubiquitination is important for IFIH1 oligomerization and activation
  • TRIM65 exerted oncogenic activities via ubiquitylation of AXIN1 to activate the CTNNB1 signaling pathway
  • TRIM65 directly bound to AXIN1 and accelerated its degradation through ubiquitylation
  • TRIM65 has an essential oncogenic role via ubiquitination of ANXA2 in urothelial carcinoma of the bladder (UCB) pathogenesis
  • TRIM65 binds to the N-terminus of TP53 tumor suppressor and thus competes with MDM2 for TP53 binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    combinatory inhibition of TRIM65 and MDM2 in lung cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpression of TRIM65 has an essential oncogenic role via ubiquitination of ANXA2 in urothelial carcinoma of the bladder pathogenesis, and could be used as a novel prognostic marker (P%ID: 30075204)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    overexpression of TRIM65 could be used therapeutic target for urothelial carcinoma of the bladder
    ANIMAL & CELL MODELS