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FLASH GENE
Symbol TRIM56 contributors: mct - updated : 20-02-2018
HGNC name tripartite motif-containing 56
HGNC id 19028
Location 7q22.1      Physical location : 100.728.785 - 100.733.887
Synonym name
  • RING finger protein 109
  • E3 ubiquitin-protein ligase TRIM56
  • Synonym symbol(s) RNF109, FLJ35608, DKFZP667O116
    EC.number 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 5.12 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D7S2498 - D7S2480 - TRIM56 - D7S477 - D7S2536 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3547 81.4 755 - 2010 21074459
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunelymph node    
     spleen    
    Reproductivefemale systemuteruscervix  
     female systemovary   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain
  • two B-box zinc finger domains (one type 1 and one type 2)
  • a coiled-coil domain
  • expression of a short segment within the very C-terminal tail of TRIM56 inhibited the replication of influenza viruses as effectively as that of full-length TRIM56 by specifically targeting viral RNA synthesis
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine TRIM56 (83.2 pc)
    Homologene
    FAMILY
  • fibrillar collagen family
  • C-V TRIM family
  • TRIM/RBCC family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acting as an ubiquitin protein ligase
  • regulator of double-stranded DNA-mediated type I interferon induction
  • its antiviral activity depended on its E3 ubiquitin ligase activity as well as the integrity of its C-terminal region but was not attributed to a general augmentation of the interferon antiviral response
  • is a novel antiviral host factor that restricts pestivirus infection
  • is an essential component of the TLR3 antiviral signaling pathway and play a role in innate antiviral immunity
  • remarkable multifaceted activity of TRIM56, which has developed multiple domains to inhibit multiple viral families
  • inhibits ovarian cancer progression by targeting VIM
  • TRIM56 is a crucial component of the cytosolic DNA sensing pathway that induces anti-DNA viral innate immunity
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • is an interferon-inducible E3 ubiquitin ligase that modulates TMEM173 to confer double-stranded DNA-mediated innate immune responses
  • positive regulator of TLR3 signaling
  • TRIM56 is the ubiquitin ligase that is degrading vimentin in Moody cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    possibility of developing a broad-spectrum, TRIM56-based antiviral approach for addition to influenza prophylaxis and/or control strategies
    ANIMAL & CELL MODELS