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FLASH GENE
Symbol TRIM56 contributors: mct - updated : 20-02-2018
HGNC name tripartite motif-containing 56
HGNC id 19028
Location 7q22.1      Physical location : 100.728.785 - 100.733.887
Synonym name
  • RING finger protein 109
  • E3 ubiquitin-protein ligase TRIM56
  • Synonym symbol(s) RNF109, FLJ35608, DKFZP667O116
    EC.number 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 5.12 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D7S2498 - D7S2480 - TRIM56 - D7S477 - D7S2536 - qter
    Authors UCSC (2009)
    Physical map
    LOC392081 7 similar to insulin receptor substrate like protein LRRN4 7q22 leucine rich repeat neuronal 4 FBXO24 7q22 F-box only protein 24 PCOLCE 7q22 procollagen C-endopeptidase enhancer AF053356_CDS3 7q22 hypothetical protein AF053356_CDS3 TFR2 7q22 transferrin receptor 2 ACTL6 7q22 actin-like 6 GNB2 7q21.1-q22.2 guanine nucleotide binding protein (G protein), beta polypeptide 2 PERQ1 7q22 PERQ amino acid rich, with GYF domain 1 RPP20 7q22 POP7 (processing of precursor, S. cerevisiae) homolog EPO 7q21.3-q22.1 erythropoietin ZAN 7q22 zonadhesin EPHB4 7q32-q36 EphB4 LOC285995 7q22.1 hypothetical LOC285995 SLC12A9 7q22 solute carrier family 12 (potassium/chloride transporters), member 9 TRIP6 7q22 thyroid hormone receptor interactor 6 ARS2 7q21 arsenate resistance protein ARS2 ACHE 7q22.1 acetylcholinesterase (YT blood group) MUC3B 7q22 mucin 3B LOC219612 7q22.1 hypothetical gene supported by AK025404 MUC17 7q22 mucin 17 TRIM56 7q11.2 tripartite motif-containing 56 SERPINE1 7q21.3-q22.1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 AP1S1 7q11.22 adaptor-related protein complex 1, sigma 1 subunit VGF 7q22 VGF nerve growth factor inducible FLJ39237 7q22.1 FLJ39237 protein MGAT3 22q13.1 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase PLOD3 7q36 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ZNHIT1 7q22.1 zinc finger, HIT domain containing 1 CLDN15 7q22 claudin 15 TTC11 7q22.1 tetratricopeptide repeat domain 11 LOC392082 7 similar to Zn-alpha-2-glycoprotein precursor FLJ14117 COL26A1 7q22.1 collagen, type XXVI, alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3547 81.4 755 - 2010 21074459
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunelymph node    
     spleen    
    Reproductivefemale systemuteruscervix  
     female systemovary   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain
  • two B-box zinc finger domains (one type 1 and one type 2)
  • a coiled-coil domain
  • expression of a short segment within the very C-terminal tail of TRIM56 inhibited the replication of influenza viruses as effectively as that of full-length TRIM56 by specifically targeting viral RNA synthesis
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine TRIM56 (83.2 pc)
    Homologene
    FAMILY
  • fibrillar collagen family
  • C-V TRIM family
  • TRIM/RBCC family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acting as an ubiquitin protein ligase
  • regulator of double-stranded DNA-mediated type I interferon induction
  • its antiviral activity depended on its E3 ubiquitin ligase activity as well as the integrity of its C-terminal region but was not attributed to a general augmentation of the interferon antiviral response
  • is a novel antiviral host factor that restricts pestivirus infection
  • is an essential component of the TLR3 antiviral signaling pathway and play a role in innate antiviral immunity
  • remarkable multifaceted activity of TRIM56, which has developed multiple domains to inhibit multiple viral families
  • inhibits ovarian cancer progression by targeting VIM
  • TRIM56 is a crucial component of the cytosolic DNA sensing pathway that induces anti-DNA viral innate immunity
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • is an interferon-inducible E3 ubiquitin ligase that modulates TMEM173 to confer double-stranded DNA-mediated innate immune responses
  • positive regulator of TLR3 signaling
  • TRIM56 is the ubiquitin ligase that is degrading vimentin in Moody cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    possibility of developing a broad-spectrum, TRIM56-based antiviral approach for addition to influenza prophylaxis and/or control strategies
    ANIMAL & CELL MODELS