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FLASH GENE
Symbol TRIM55 contributors: KTN/npt - updated : 03-02-2009
HGNC name tripartite motif-containing 55
HGNC id 14215
Location 8q13.1      Physical location : 67.039.277 - 67.087.716
Synonym name
  • ring finger protein 29
  • muscle specific ring finger 2
  • muscle-specific RING finger protein 2
  • Synonym symbol(s) MURF2, MURF-2, RNF29
    DNA
    TYPE functioning gene
    STRUCTURE 48.44 kb     11 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D8S553 - D8S533 - TRIM55 - D8S1797 - D8S1785 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2771 60.3 548 - Iakovenko, Pizon
    11 splicing 2859 60 540 - Iakovenko, Pizon
  • having an additional exon within the coding region compared to variant 1, which causes a frameshift
  • 9 splicing 2483 50.7 452 - Iakovenko, Pizon
  • lacking an in-frame exon within the coding region compared to variant 1
  • 5 splicing 1850 26.7 241 . detected specifically in cardiac muscle Iakovenko, Pizon
  • lacking four exons within the coding region compared to variant 1
  • remaining the same translation frame
  • may bind variants 1, 2 and 3
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveliver   moderately
    Respiratoryrespiratory tractlarynx  moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatum  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text abundant in the fetal heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING-type zinc finger
  • a B-box type-2 zinc finger
  • a coiled-coil domain
  • a COS (C-terminal subgroup one signature) domain
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Trim55 (85.8 pc)
    ortholog to rattus Trim55 (85.3 pc)
    Homologene
    FAMILY
  • C-II TRIM family
  • MURF subfamily
  • RBCC family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may regulate gene expression and protein turnover in muscle cells
  • acting as a transient adaptor
  • playing a regulatory role in the assembly of sarcomeres
  • acting as an ubiquitin-protein ligase
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homooligomer
  • heterooligomer (probable)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with titin/TTN
  • myosins
  • SQSTM1
  • NBR1
  • TRIM63
  • TRIM54
  • cell & other
    REGULATION
    Other downregulated during cardiac development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS