Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TRIM52 contributors: mct - updated : 03-09-2020
HGNC name tripartite motif-containing 52
HGNC id 19024
Location 5q35.3      Physical location : 180.683.387 - 180.688.119
Synonym name RING finger protein 102
Synonym symbol(s) RNF102, MGC16175
EC.number 2.3.2.27
DNA
TYPE functioning gene
STRUCTURE 11.40 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D5S408 - D5S2006 - TRIM52 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3491 34.5 297 - 2019 31002351
2 - 2512 - 285 - 2019 31002351
2 - 2856 - - - 2019 31002351
2 - 3225 - 277 - 2019 31002351
2 - 3051 - 272 - 2019 31002351
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger, RING domain essential for its activation of the NFKB1 signal
  • a B box domain type 2
  • HOMOLOGY
    Homologene
    FAMILY
  • RBCC (TRIM family)
  • C-V TRIM family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • both TRIM52 and TRIM41 have dramatically expanded RING domains compared with the rest of the TRIM multigene family
  • is a novel noncanonical antiviral TRIM gene with a unique expanded RING domain
  • was a positive regulator of the NFKB1 pathway
  • is required for basic cellular functions in normal cells
  • non-redundant TRIM52 function that is required for optimal proliferation
  • TRIM52 plays likely an oncogenic role in ovarian cancer development associated with the NFKB1 signal pathway
  • might exert oncogenic role in Colorectal cancer via regulating the STAT3 signaling pathway
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRIM52 was a fibrosis promoter in hepatic fibrosis in vitro, likely through PPM1A-mediated TGB1/Smad pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    TRIM52-RACK1 in oral squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be a potential target for ovarian cancer therapy
    ANIMAL & CELL MODELS