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FLASH GENE
Symbol TRIM48 contributors: mct - updated : 19-09-2019
HGNC name tripartite motif-containing 48
HGNC id 19021
Location 11q11      Physical location : 55.029.657 - 55.038.594
Synonym symbol(s) RNF101, MGC4827
DNA
TYPE functioning gene
STRUCTURE 8.96 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D11S1326 - D11S4165 - cen - TRIM48 - D11S1313 - D11S1357 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1467 26.3 224 - 2017 29186683
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain
  • a B30.2/SPRY domain
  • HOMOLOGY
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • identifying specific cell compartments
  • facilitates oxidative stress-induced MAP3K5 activation and cell death through ubiquitination-dependent degradation of PRMT1
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRIM48 orchestrates the regulation of oxidative stress-induced MAP3K5 activation
  • TRIM48 facilitates MAP3K5 activation by promoting K48-linked polyubiquitination and degradation of PRMT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS